IER3 Antibodies

IER3 antibodies are designed to specifically bind to the Immediate Early Response 3 (IER3) protein, which is involved in cell survival, stress response, and immune regulation. IER3, also known as IEX-1, plays a crucial role in cellular signaling pathways, particularly in the modulation of apoptosis and inflammatory responses. IER3 expression is rapidly induced by various stressors, including oxidative stress, cytokines, and UV radiation.

Content

IER3 is a stress-responsive gene that encodes a protein involved in regulating apoptosis and cell survival. It acts as a mediator in multiple signaling pathways, such as NF-κB and MAPK, influencing cellular responses to external stimuli. Abnormal expression of IER3 has been associated with various pathological conditions, including cancer, autoimmune disorders, and inflammatory diseases. 

Application

IER3 antibodies are widely used in:

• Western Blotting (WB): For detecting and analyzing IER3 protein expression in cell and tissue samples, helping to understand its role in signaling pathways.
• Immunohistochemistry (IHC): To localize IER3 expression within tissue sections, providing insights into tissue-specific expression patterns, particularly in cancerous or inflamed tissues.
• Flow Cytometry: Employed to assess the expression of IER3 on a cellular level, which is useful for phenotyping and studying immune cell behavior.
• Immunoprecipitation (IP): Used to isolate IER3 from cell lysates for downstream applications, including protein-protein interaction studies.
• Enzyme-Linked Immunosorbent Assay (ELISA): For quantifying IER3 protein levels in biological samples, aiding in the investigation of its role in stress responses and disease.

These applications allow researchers to study the function of IER3 in various cellular processes, including cell cycle regulation, apoptosis, and immune responses, which can be pivotal for understanding its involvement in diseases and developing potential therapeutic strategies.