HGF Antibodies

Hepatocyte Growth Factor (HGF) is a multifunctional growth factor involved in cell proliferation, motility, and morphogenesis. HGF plays a key role in organ development, tissue regeneration, and wound healing by activating its receptor, c-Met, a receptor tyrosine kinase. HGF signaling influences various cellular processes, including angiogenesis, epithelial-mesenchymal transition (EMT), and tissue repair. Dysregulation of the HGF/c-Met pathway is associated with cancer progression and metastasis. HGF antibodies are used to detect and study the HGF protein in biological samples and to explore its function in development, disease, and cellular signaling pathways.

Content on HGF Antibodies

HGF is produced primarily by mesenchymal cells and acts on epithelial and endothelial cells by binding to the c-Met receptor. Upon activation of c-Met, HGF triggers downstream signaling cascades such as the MAPK/ERK and PI3K/AKT pathways, which promote cell survival, proliferation, and migration. HGF is critical in embryonic development, liver regeneration, and tissue repair processes. Additionally, aberrant HGF signaling has been implicated in tumor growth, angiogenesis, and resistance to cancer therapies.

Application of HGF Antibodies

• Enzyme-linked Immunosorbent Assay (ELISA): HGF antibodies are employed in ELISA assays to measure HGF levels in serum, plasma, or tissue culture supernatants. ELISA provides quantitative data on HGF expression, which is essential for studying its role in liver regeneration, tissue repair, and cancer progression.
• Immunohistochemistry (IHC) and Immunofluorescence (IF): HGF antibodies are applied in IHC and IF to visualize the localization and distribution of HGF in tissue sections. These techniques are used to study HGF expression in various organs, such as the liver, lungs, and kidneys, and to explore how its expression correlates with tissue repair or tumor progression.
• Signal Transduction Studies: HGF antibodies are essential tools for studying the HGF/c-Met signaling axis. By using HGF antibodies in functional assays, researchers can investigate how HGF binding to c-Met activates downstream signaling pathways like MAPK/ERK and PI3K/AKT, which promote cell growth, migration, and survival. These studies are crucial in understanding HGF’s role in cellular processes like EMT and angiogenesis.
• Cancer Research: The HGF/c-Met pathway is often dysregulated in cancer, contributing to tumor growth, metastasis, and resistance to therapy. HGF antibodies are employed in cancer research to investigate how elevated HGF levels support tumorigenesis and to explore therapeutic strategies that target the HGF/c-Met axis to inhibit tumor progression.

HGF antibodies are indispensable tools for studying the molecular mechanisms behind tissue regeneration, wound healing, cancer progression, and angiogenesis, providing insights into both normal biological processes and disease pathology.