HBV Antibodies

HBV antibodies are developed to specifically target the Hepatitis B Virus (HBV), a DNA virus that causes both acute and chronic liver infections. HBV is transmitted through contact with infected bodily fluids, such as blood, semen, and saliva. Chronic HBV infection can lead to severe liver conditions, including cirrhosis, liver failure, and hepatocellular carcinoma. 

Content

HBV is a member of the Hepadnaviridae family, and it primarily infects liver cells (hepatocytes). The immune system responds by producing specific antibodies against these proteins:

  • Anti-HBs: Antibodies against the HBV surface antigen (HBsAg). The presence of anti-HBs indicates immunity to HBV, either through vaccination or recovery from a past infection.
  • Anti-HBc: Antibodies against the core antigen (HBcAg). Detection of anti-HBc, particularly the IgM form, suggests recent or ongoing infection, while IgG anti-HBc persists for life, indicating past or chronic infection.
  • Anti-HBe: Antibodies against the e antigen (HBeAg). The presence of anti-HBe suggests a lower level of viral replication and can indicate a transition to a less active phase of chronic infection.

Application

HBV antibodies are applied in multiple diagnostic and research settings, including:

  • Rapid Diagnostic Tests (RDTs): HBV antibodies are used in point-of-care tests for quick screening. These tests are particularly useful in field settings and low-resource areas to identify active HBV infection or verify immunity, facilitating the control of HBV transmission.
  • Western Blotting (WB): Applied for detailed analysis of HBV proteins and antibody responses. WB can be used in research to study the viral structure, protein expression, and host immune responses, contributing to vaccine development and therapeutic studies.
  • Flow Cytometry: Utilized in research to analyze specific B-cell responses against HBV antigens. This can provide insights into how the immune system responds to HBV infection or vaccination, which is critical for understanding protective immunity and designing new vaccines.

These applications make HBV antibodies essential tools for understanding the natural history of Hepatitis B infection, improving diagnostic accuracy, and guiding therapeutic and preventive strategies.

AffiAB® Anti-HBV Pres1 Antibody
CAT# AFG-BMG-2441
Size: 100 µl
339.85 339.85 USD
AffiAB® Anti-HBV PreS2 (H.11) Antibody
CAT# AFG-BMG-0321
Size: 100 µl
219.08 219.08 USD
AffiAB® Anti-HBsAg (HBV) Purified [HB5]
CAT# AFG-EXB-0227
Size: 0.1 mg
165.50 165.5 USD
AffiAB® Anti-HBsAg (HBV) Purified [HB3]
CAT# AFG-EXB-0226
Size: 0.1 mg
165.50 165.5 USD