GHRH Antibodies

GHRH (Growth Hormone-Releasing Hormone) is a peptide hormone that stimulates the release of growth hormone (GH) from the anterior pituitary gland. It plays a critical role in regulating growth, metabolism, and tissue repair. GHRH is synthesized in the hypothalamus and acts on the growth hormone-releasing hormone receptor (GHRHR) in pituitary somatotroph cells, initiating the synthesis and secretion of GH. Abnormalities in GHRH signaling are linked to various growth disorders and metabolic diseases.

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GHRH antibodies are developed to specifically recognize and bind to the GHRH peptide, enabling researchers to study its expression and regulation in tissues. These antibodies are used in various experimental applications, including immunohistochemistry (IHC), enzyme-linked immunosorbent assays (ELISA), immunoprecipitation (IP), and Western blotting, to detect and quantify GHRH in biological samples.

Applications
  • Growth Hormone Regulation Studies: GHRH antibodies are critical in studying the mechanisms by which GHRH regulates growth hormone release from the pituitary gland. By detecting GHRH levels in tissue samples, researchers can better understand the dynamics of growth hormone secretion in normal and pathological conditions.
  • Neuroendocrine Research: GHRH is an essential component of the hypothalamic-pituitary axis. Antibodies against GHRH are used to study its role in neuroendocrine signaling and its interactions with other hormones such as somatostatin and insulin-like growth factor 1 (IGF-1), which collectively regulate growth and metabolism.
  • Metabolic Disease Research: Abnormal GHRH signaling has been implicated in metabolic disorders such as obesity and insulin resistance. GHRH antibodies are employed to investigate the relationship between GHRH levels and metabolic syndromes, offering potential insights into therapeutic strategies targeting the GHRH-GH axis.
  • Cancer Research: GHRH and its receptor are also expressed in certain tumors, including pituitary adenomas and neuroendocrine cancers. GHRH antibodies are used to explore the expression of GHRH in tumor tissues and assess its role in tumor growth and proliferation, particularly in cases where GHRH acts as an autocrine or paracrine growth factor.
  • Growth Disorders: GHRH antibodies are valuable in research focused on growth disorders such as dwarfism, gigantism, and acromegaly. By detecting GHRH expression in patients with abnormal growth, these antibodies help elucidate the molecular mechanisms underlying growth hormone dysregulation.
  • Therapeutic Development: GHRH analogs and antagonists are being explored for their potential in treating growth hormone deficiencies and excesses. GHRH antibodies play a role in preclinical studies to evaluate the efficacy and specificity of these therapeutic agents in modulating GHRH activity.

By using GHRH antibodies in these research areas, scientists can gain a deeper understanding of the physiological and pathological roles of GHRH, contributing to the development of novel therapies for growth-related disorders and metabolic diseases.

AffiAB® Rabbit Anti-GHRH Antibody
CAT# AFG-DDA-5646
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit Anti-GHRH Receptor Antibody
CAT# AFG-DDA-4716
Size: 100 μL
308.75 308.75 USD
AffiAB® GHRHR Polyclonal Antibody
CAT# AFG-PAB-05646
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® GHRH Polyclonal Antibody
CAT# AFG-PAB-05645
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® Rabbit anti-GHRH Receptor Antibody
CAT# AFG-YBP-3608
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-GHRH Antibody
CAT# AFG-YBP-3607
Size: 100 µL
457.00 457.0 USD
AffiAB® GHRHR Antibody
CAT# AFG-IVA-11462
Size: 100 µg
Terminal: N/A
719.15 719.15 USD
AffiAB® GHRH Antibody
CAT# AFG-IVA-11461
Size: 100 µL
Terminal: N/A
705.65 705.65 USD