FXR Antibodies

FXR (Farnesoid X Receptor) is a nuclear receptor that plays a critical role in the regulation of bile acid metabolism, lipid homeostasis, glucose metabolism, and energy balance. FXR is primarily expressed in the liver, intestines, kidneys, and adrenal glands. It functions as a ligand-activated transcription factor, regulating genes involved in bile acid synthesis and transport. 

Content

FXR antibodies are specifically designed to detect the FXR protein in various experimental settings. These antibodies are utilized in Western blotting, immunohistochemistry (IHC), immunoprecipitation (IP), and enzyme-linked immunosorbent assays (ELISA) to study FXR expression, localization, and functional role in bile acid metabolism and metabolic disorders. 

Applications

• Bile Acid Metabolism Research: FXR is a key regulator of bile acid homeostasis, and FXR antibodies are used to study its role in controlling bile acid synthesis and transport in the liver and intestines. These antibodies help elucidate how FXR modulates gene expression to maintain bile acid balance, which is critical in liver health and prevention of cholestasis.
• Lipid Metabolism and Fatty Liver Disease: FXR plays a role in lipid homeostasis and has been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). FXR antibodies are applied to study how FXR influences lipid storage and metabolism in hepatocytes, providing insights into the molecular basis of fatty liver disease and potential therapeutic targets.
• Glucose Metabolism and Diabetes: FXR also impacts glucose metabolism by regulating insulin sensitivity and gluconeogenesis. FXR antibodies are crucial in research focused on metabolic diseases like type 2 diabetes, helping to explore the pathways through which FXR controls glucose levels and insulin signaling in the liver and peripheral tissues.
• Cancer Research: FXR has been implicated in various cancers, including liver and colon cancer, where its regulatory role in bile acids and lipid metabolism may influence tumor growth. FXR antibodies are used to assess the expression of FXR in cancerous tissues and investigate its potential as a therapeutic target for metabolic-related cancers.
• Drug Development and Therapeutics: Due to its regulatory role in metabolism, FXR is considered a target for drug development in treating metabolic disorders such as cholestasis and diabetes. FXR antibodies are used in drug screening assays to evaluate the efficacy of FXR modulators, providing critical insights into the development of novel therapeutics.

By utilizing FXR antibodies in experimental research, scientists can dissect the molecular mechanisms that regulate bile acid, lipid, and glucose metabolism, offering potential therapeutic strategies for managing metabolic diseases and liver disorders.