Fibronectin Antibodies
Fibronectin antibodies are specialized reagents designed to detect and study fibronectin, a high-molecular-weight glycoprotein found in the extracellular matrix (ECM) and blood plasma. Fibronectin plays a critical role in cell adhesion, migration, wound healing, and tissue repair.
Content: Fibronectin exists in two main forms: soluble plasma fibronectin, which circulates in the blood, and insoluble cellular fibronectin, which is a component of the ECM.
Fibronectin antibodies are designed to target:
- Total Fibronectin: These antibodies recognize fibronectin in its various forms, allowing researchers to study overall fibronectin expression in tissues, cells, or plasma.
- Cellular Fibronectin: Antibodies specific to cellular fibronectin isoforms help in studying fibronectin's role in the ECM, particularly during processes like tissue remodeling, fibrosis, and cancer progression.
Applications:
- ardiovascular Research:
- Vascular Remodeling and Fibrosis: Fibronectin is involved in vascular remodeling, atherosclerosis, and cardiac fibrosis. Fibronectin antibodies are used to study how fibronectin expression is regulated during these processes, providing insights into the development of cardiovascular diseases and potential therapeutic interventions.
- Diagnostic Applications:
- Biomarker Discovery: Elevated fibronectin levels are often observed in conditions like cancer, liver fibrosis, cardiovascular diseases, and chronic wounds. Fibronectin antibodies can be used to detect and quantify fibronectin in biological fluids (e.g., plasma, serum, urine) as a biomarker for disease diagnosis and prognosis.
- Biotechnology and Therapeutic Research:
- Drug Screening: Fibronectin antibodies can be used in drug screening assays to evaluate compounds that modulate fibronectin expression or inhibit fibronectin-integrin interactions. This is important for developing therapeutics that target the ECM to prevent tumor progression or fibrosis.
In summary, fibronectin antibodies are powerful tools for studying the role of fibronectin in cell biology, disease pathology, and tissue engineering. They are used to investigate how fibronectin contributes to processes like cell adhesion, migration, wound healing, cancer metastasis, and fibrosis.
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