CSN Antibodies

CSN (COP9 Signalosome) antibodies target proteins within the COP9 signalosome complex, which is a multi-subunit protein complex that regulates various cellular processes, including protein degradation, cell cycle control, DNA damage response, and transcriptional regulation. 

Content of CSN Antibody

CSN antibodies are typically monoclonal or polyclonal and are used to specifically recognize different subunits of the COP9 signalosome complex (such as CSN1, CSN3, CSN5, etc.). These antibodies are employed in a variety of research techniques, including Western blotting, immunoprecipitation, immunofluorescence (IF), and immunohistochemistry (IHC), to study the role of the CSN complex in regulating protein turnover, cell cycle, and stress responses.

• CSN5 (Jab1): The catalytic subunit responsible for deneddylating cullin-RING ligases.
• CSN1 through CSN8: Form the core structure of the complex, coordinating the regulation of CRLs and other pathways.

Application of CSN Antibody

• Protein Degradation and Ubiquitin-Proteasome System Research: CSN antibodies are essential in studying the role of the COP9 signalosome in regulating the stability and degradation of proteins via the ubiquitin-proteasome system. CSN5 antibodies, in particular, are used to investigate how the deneddylation of cullins affects the activity of CRLs and protein degradation. 
• Cell Cycle Regulation: The COP9 signalosome plays a critical role in cell cycle control by regulating the activity of CRLs, which are involved in the degradation of cell cycle regulators. CSN antibodies are used to study how the signalosome controls the ubiquitination and subsequent degradation of proteins that regulate cell cycle transitions, such as cyclins and cyclin-dependent kinase inhibitors. T
• DNA Damage Response and Repair: CSN antibodies are applied in research focusing on the role of the COP9 signalosome in the DNA damage response. By regulating the degradation of proteins involved in DNA repair, the CSN complex contributes to maintaining genomic stability. Researchers use CSN antibodies to investigate how the signalosome modulates the activity of CRLs that target DNA repair proteins, and how its dysregulation leads to increased sensitivity to DNA damage and cancer development.
• Cancer Research: The COP9 signalosome is frequently dysregulated in cancer, where its altered activity can contribute to uncontrolled cell growth, resistance to apoptosis, and tumor progression. CSN antibodies, especially CSN5 antibodies, are used to study the role of the signalosome in cancer cell proliferation and survival.

CSN antibodies are critical tools for understanding the regulation of protein degradation, cell cycle control, and DNA repair by the COP9 signalosome complex. These antibodies provide valuable insights into how CSN dysfunction contributes to cancer, neurodegenerative diseases, and immune-related disorders.