PD-L1 Antibodies 

Programmed Cell Death Protein 1 (PD-1), also known as CD279, is a critical immune checkpoint receptor expressed on T cells, B cells, and natural killer (NK) cells. PD-1 functions as a negative regulator of immune activation by binding to its ligands, PD-L1 and PD-L2, which are upregulated in various tumor microenvironments. 

Content and Structural Features of PD-1 and PD-L1 Antibodies

PD-1 and PD-L1 antibodies are engineered monoclonal immunoglobulins (IgG) designed to competitively inhibit PD-1/PD-L1 interactions, enhancing T cell function. Structurally, they consist of a variable domain recognizing PD-1 or PD-L1 and a constant Fc region, which may influence immune effector functions.

Key PD-L1 Antibodies
  1. Atezolizumab (Tecentriq®): A fully humanized IgG1 antibody targeting PD-L1, preventing interaction with PD-1 and B7.1.
  2. Durvalumab (Imfinzi®): A human IgG1 mAb targeting PD-L1, used primarily in lung and bladder cancer.
  3. Avelumab (Bavencio®): A fully human IgG1 mAb with both immune checkpoint inhibition and Fc-mediated effector functions.
Applications in Immunotherapy

PD-1 and PD-L1 antibodies have been extensively utilized in treating solid tumors, hematological malignancies, and autoimmune diseases. Their applications include:

Oncology
  • PD-1 and PD-L1 inhibitors have significantly improved survival in various cancers by enhancing T cell-mediated cytotoxicity. They are approved for:
  • Non-Small Cell Lung Cancer (NSCLC): Monotherapy or in combination with chemotherapy.
  • Melanoma: First-line treatment for advanced/metastatic disease.
  • Hodgkin's Lymphoma: Effective in relapsed/refractory cases, particularly after autologous stem cell transplantation.

Head and Neck Squamous Cell Carcinoma (HNSCC): Treatment of recurrent or metastatic disease.

Autoimmune and Infectious Diseases

While primarily utilized in oncology, PD-1 and PD-L1 blockade has shown potential in:

  • Chronic infections (e.g., HIV, hepatitis B, and tuberculosis) by reinvigorating exhausted T cells.
  • Autoimmune disorders: Experimental applications in systemic lupus erythematosus (SLE) and type 1 diabetes by modulating T cell tolerance.

PD-1 and PD-L1 antibodies represent a paradigm shift in immunotherapy, particularly for cancer treatment. Their efficacy in reinvigorating exhausted T cells has dramatically improved outcomes in multiple malignancies. Ongoing research focuses on expanding indications, optimizing combination therapies, and mitigating immune-related adverse effects (irAEs) such as pneumonitis, colitis, and endocrinopathies.

AffiAB® PD-L1- IMF Antibody
CAT# AFG-BMG-0230
Size: 0.1 mL
259.77 259.77 USD
AffiAB® PD-L1 - Tec Antibody
CAT# AFG-BMG-0229
Size: 0.1 mL
259.77 259.77 USD
AffiAB® PD-L1 Antibody
CAT# AFG-BMG-0103
Size: 0.1 mL
206.54 206.54 USD
AffiAB®​ Anti-Canine PD-L1
CAT# AFG-QDB-1481
Size: 100 μg
683.00 683.0 USD
AffiAB®​ Anti-PD-L1 Antibody
CAT# AFG-QDB-1463
Size: 100 μ L
444.65 444.65000000000003 USD
AffiAB® Anti-PD-L1 CD274 Antibody
CAT# AFG-BRB-07361
Size: 0.1mg
756.15 756.15 USD
AffiAB® Anti-PD-L1 VHH Antibody
CAT# AFG-JTD-14
Size: 100 µg
372.60 372.6 USD
AffiAB® Mouse PD-L1 Antibody
CAT# AFG-SYP-1935
Size: 150 μg
458.00 458.0 USD
576.25 576.25 USD
784.00 784.0 USD
475.30 475.3 USD
AffiAB® Ribosome-inactivating protein PD-L1/PD-L2 Polyclonal Antibody
CAT# AFG-PAB-17148
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® Anti-PD-L1 Antibody [PD01-02]
CAT# AFG-HB-2936
Size: 100 μL
496.50 496.5 USD
AffiAB® Anti-PD-L1 Antibody [JJ08-95]
CAT# AFG-HB-2934
Size: 100 μL
496.50 496.5 USD
AffiAB® Purified Anti-Human CD274/PD-L1 Antibody
CAT# AFG-DDF-2397
Size: 100 μg
375.00 375.0 USD
AffiAB® PE/Cyanine7 Anti-Human CD274/PD-L1 Antibody
CAT# AFG-DDF-1998
Size: 100 Tests
600.00 600.0 USD
AffiAB® PE/Cyanine5.5 Anti-Mouse CD274/PD-L1 Antibody
CAT# AFG-DDF-1893
Size: 100 Tests
435.00 435.0 USD
AffiAB® PE/Cyanine5 Anti-Human CD274/PD-L1 Antibody
CAT# AFG-DDF-1675
Size: 100 Tests
600.00 600.0 USD
AffiAB® Biotin Anti-Mouse CD274/PD-L1 Antibody
CAT# AFG-DDF-1067
Size: 100 μg
397.50 397.5 USD
AffiAB® APC Anti-Mouse CD274/PD-L1 Antibody
CAT# AFG-DDF-0876
Size: 100 μg
555.00 555.0 USD
AffiAB® APC Anti-Mouse CD274/PD-L1 Antibody
CAT# AFG-DDF-0875
Size: 100 Tests
405.00 405.0 USD
AffiAB® APC Anti-Human CD274/PD-L1 Antibody
CAT# AFG-DDF-0769
Size: 100 Tests
487.50 487.5 USD
AffiAB® Purified Anti-Mouse CD274/PD-L1 Antibody
CAT# AFG-DDF-2460
Size: 100 μg
330.00 330.0 USD