PD-1 Antibodies 

Programmed Cell Death Protein 1 (PD-1), also known as CD279, is a critical immune checkpoint receptor expressed on T cells, B cells, and natural killer (NK) cells. PD-1 functions as a negative regulator of immune activation by binding to its ligands, PD-L1 and PD-L2, which are upregulated in various tumor microenvironments. 

Content and Structural Features of PD-1 Antibodies

PD-1 antibodies are engineered monoclonal immunoglobulins (IgG) designed to competitively inhibit PD-1/PD-L1 interactions, enhancing T cell function. Structurally, they consist of a variable domain recognizing PD-1 and a constant Fc region, which may influence immune effector functions.

Key PD-1 Antibodies
  • Nivolumab (Opdivo®): A fully human IgG4 mAb with a hinge-stabilized structure to minimize antibody-dependent cytotoxicity.
  • Pembrolizumab (Keytruda®): A humanized IgG4 mAb with similar immune checkpoint inhibition properties.
  • Cemiplimab (Libtayo®): A fully human IgG4 antibody with high affinity for PD-1, used in certain cutaneous malignancies.
Applications in Immunotherapy

PD-1 antibodies have been extensively utilized in treating solid tumors, hematological malignancies, and autoimmune diseases. Their applications include:

Oncology: PD-1 inhibitors have significantly improved survival in various cancers by enhancing T cell-mediated cytotoxicity. They are approved for:

  • Non-Small Cell Lung Cancer (NSCLC): Monotherapy or in combination with chemotherapy.
  • Melanoma: First-line treatment for advanced/metastatic disease.
  • Hodgkin's Lymphoma: Effective in relapsed/refractory cases, particularly after autologous stem cell transplantation.
  • Gastrointestinal Cancers: Approved for MSI-high colorectal cancers and certain gastric cancers.

Autoimmune and Infectious Diseases: While primarily utilized in oncology, PD-1 blockade has shown potential in:

  • Chronic infections (e.g., HIV, hepatitis B, and tuberculosis) by reinvigorating exhausted T cells.
  • Autoimmune disorders: Experimental applications in systemic lupus erythematosus (SLE) and type 1 diabetes by modulating T cell tolerance.

PD-1 antibodies represent a paradigm shift in immunotherapy, particularly for cancer treatment. Their efficacy in reinvigorating exhausted T cells has dramatically improved outcomes in multiple malignancies. Ongoing research focuses on expanding indications, optimizing combination therapies, and mitigating immune-related adverse effects (irAEs) such as pneumonitis, colitis, and endocrinopathies. 

AffiAB® PD-1 Antibody
CAT# AFG-BMG-0086
Size: 0.1 mL
117.81 117.81 USD
AffiAB®​ Anti-Canine PD-1
CAT# AFG-QDB-1480
Size: 100 μg
683.00 683.0 USD
AffiAB®​ Anti-PD-1 Antibody
CAT# AFG-QDB-1462
Size: 100 μ L
400.55 400.55 USD
AffiAB® Anti-PD-1 PDCD1 Antibody
CAT# AFG-BRB-23225
Size: 0.1mg
756.15 756.15 USD
857.40 857.4 USD
AffiAB® Anti-PD-1 PDCD1 Antibody
CAT# AFG-BRB-07363
Size: 0.1mg
756.15 756.15 USD
576.25 576.25 USD
576.25 576.25 USD
475.30 475.3 USD
AffiAB® gpd-1 Polyclonal Antibody
CAT# AFG-PAB-05841
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® Purified Anti-Human CD279/PD-1 Antibody
CAT# AFG-DDF-2399
Size: 100 μg
483.00 483.0 USD
AffiAB® Purified Anti-Human CD279/PD-1 Antibody
CAT# AFG-DDF-2398
Size: 100 μg
360.00 360.0 USD
660.00 660.0 USD
435.00 435.0 USD
AffiAB® PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-2070
Size: 100 μg
645.00 645.0 USD
AffiAB® PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-2069
Size: 100 Tests
435.00 435.0 USD
600.00 600.0 USD
AffiAB® PE/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-1895
Size: 100 Tests
435.00 435.0 USD
AffiAB® PE Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-1523
Size: 100 μg
480.00 480.0 USD
AffiAB® PE Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-1522
Size: 100 Tests
382.50 382.5 USD
AffiAB® FITC Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-1230
Size: 100 μg
480.00 480.0 USD
AffiAB® FITC Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-1229
Size: 100 Tests
382.50 382.5 USD
AffiAB® Biotin Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-1068
Size: 100 μg
472.50 472.5 USD
AffiAB® APC Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-0878
Size: 100 μg
555.00 555.0 USD
AffiAB® APC Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-0877
Size: 100 Tests
405.00 405.0 USD
403.00 403.0 USD
AffiAB® AF647 Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-0362
Size: 100 μg
600.00 600.0 USD
AffiAB® AF647 Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-0361
Size: 100 Tests
435.00 435.0 USD
352.50 352.5 USD
372.00 372.0 USD
352.50 352.5 USD
AffiAB® Purified Anti-Mouse CD279/PD-1 Antibody
CAT# AFG-DDF-2461
Size: 100 μg
342.00 342.0 USD