CFHR Antibodies

CFHR (Complement Factor H-Related) antibodies are designed to target proteins in the CFHR family, which play a significant role in the regulation of the complement system, particularly in controlling the alternative pathway. The CFHR proteins (CFHR1, CFHR2, CFHR3, CFHR4, and CFHR5) are structurally related to complement factor H (CFH), a major regulator of complement activity that protects host cells from damage by inhibiting complement activation on self-surfaces. conditions.

Content of CFHR Antibodies

CFHR antibodies are primarily monoclonal or polyclonal antibodies used to specifically detect different CFHR proteins. These antibodies are key in studying the role of CFHRs in complement regulation and related diseases. 

  • CFHR1: Plays a role in controlling complement activation and has been associated with protective effects against certain complement-mediated diseases.
  • CFHR3: Implicated in the pathogenesis of AMD and other complement-related disorders.
  • CFHR5: Linked to familial CFHR5 nephropathy, a kidney disease characterized by complement-mediated glomerulonephritis.
Application of CFHR Antibodies
  • Complement System Research: CFHR antibodies are crucial in studying the complement system, particularly the alternative pathway, by examining how CFHR proteins regulate complement activation. Researchers use CFHR antibodies to explore the interactions between CFHR proteins and complement factor H, as well as their roles in preventing excessive complement activation that can lead to tissue damage.
  • Disease Mechanism Studies: CFHR antibodies are applied in research focused on diseases like aHUS, AMD, and dense deposit disease (DDD). In aHUS, for example, mutations or deletions in CFHR genes can cause dysregulated complement activity, leading to kidney damage. CFHR antibodies are used to detect the expression of these proteins in patient samples to better understand the molecular mechanisms behind these diseases.
  • Therapeutic Development: Targeting the complement pathway with CFHR antibodies holds therapeutic potential. Researchers are investigating how to manipulate CFHR levels or function to treat complement-mediated diseases. CFHR antibodies are used in preclinical studies to explore therapeutic interventions aimed at restoring normal complement regulation in diseases caused by CFHR dysregulation.
  • Immunohistochemistry (IHC) and Immunofluorescence (IF): CFHR antibodies are often employed in IHC and IF to localize CFHR proteins in tissues, providing insights into their distribution and function. This is particularly useful in studying kidney diseases where CFHR proteins are involved in complement-mediated glomerular injury.

CFHR antibodies are valuable tools for understanding the regulation of the complement system and investigating their roles in immune-related diseases, helping in both basic research and clinical diagnostics.


AffiAB® Rabbit anti-CFHR1 Antibody
CAT# AFG-DDA-0783
Size: 100 μL
256.50 256.5 USD
AffiAB® CFHR5 Polyclonal Antibody
CAT# AFG-PAB-02662
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® CFHR3 Polyclonal Antibody
CAT# AFG-PAB-02661
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® CFHR2 Polyclonal Antibody
CAT# AFG-PAB-02660
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® CFHR1 Polyclonal Antibody
CAT# AFG-PAB-02659
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® Rabbit anti-CFHR1 Antibody
CAT# AFG-YBP-1985
Size: 100 µL
457.00 457.0 USD
AffiAB® CFHR5 Antibody
CAT# AFG-IVA-06041
Size: 100 µL
Terminal: N/A
773.15 773.15 USD
AffiAB® CFHR4 Antibody
CAT# AFG-IVA-06040
Size: 25 µL
Terminal: C-terminal region
378.95 378.95 USD
AffiAB® CFHR3 Antibody
CAT# AFG-IVA-06039
Size: 25 µL
Terminal: Middle region
378.95 378.95 USD
AffiAB® CFHR2 Antibody
CAT# AFG-IVA-06038
Size: 100 µg
Terminal: N/A
705.65 705.65 USD
AffiAB® CFHR1 Antibody
CAT# AFG-IVA-06037
Size: 100 µL
Terminal: N/A
705.65 705.65 USD