C5AR1 Antibodies

C5AR1 antibodies are developed to target the Complement Component 5a Receptor 1 (C5AR1), also known as CD88. C5AR1 is a G-protein-coupled receptor (GPCR) that binds to the anaphylatoxin C5a, a potent inflammatory mediator generated during the activation of the complement system. This receptor is primarily expressed on immune cells, such as neutrophils, macrophages, and dendritic cells, and plays a crucial role in mediating inflammatory and immune responses.

Content

C5AR1 is a critical component of the immune response, facilitating the recruitment and activation of immune cells to sites of infection or tissue damage. Upon binding to C5a, C5AR1 activates intracellular signaling pathways that lead to the release of pro-inflammatory cytokines, chemotaxis, and the enhancement of phagocytic activity. While these responses are vital for fighting infections, excessive or uncontrolled C5AR1 activation can contribute to pathological inflammation, as seen in conditions like autoimmune diseases, sepsis, and chronic inflammatory disorders. 

Application

C5AR1 antibodies are applied in a variety of research and diagnostic techniques, including:

  • Immunofluorescence (IF): Allows for detailed visualization of C5AR1 at the cellular level, revealing its localization on immune cells and its interactions with other proteins. IF is particularly useful for studying receptor trafficking, internalization, and regulation under inflammatory conditions.
  • Flow Cytometry: Applied to analyze C5AR1 expression on the surface of immune cells, such as neutrophils and macrophages. Flow cytometry can quantify receptor density and help investigate how C5AR1 expression is modulated in response to various stimuli, drugs, or during disease progression.
  • Immunoprecipitation (IP): Used to isolate C5AR1 from complex protein mixtures, facilitating the study of its interactions with signaling molecules and other cell surface receptors. IP can help elucidate how C5AR1 signaling is regulated and identify potential targets for therapeutic intervention.

These applications make C5AR1 antibodies crucial tools for advancing research on immune responses and inflammatory pathways. They enable scientists to explore the role of C5AR1 in conditions ranging from sepsis and autoimmune diseases to cancer, providing a basis for the development of therapies aimed at modulating C5AR1 activity to control inflammation and improve immune regulation.

AffiAB® Anti-CD88 C5AR1 Antibody
CAT# AFG-BRB-11593
Size: 100 μL
663.00 663.0 USD
542.85 542.85 USD
AffiAB® Anti-CD88 C5AR1 Antibody
CAT# AFG-BRB-02777
Size: 100 μL
688.65 688.65 USD
AffiAB® Rabbit Anti-CD88/C5AR1 Polyclonal Antibody
CAT# AFG-KMD-5389
Size: 100 μL
815.00 815.0 USD
AffiAB® Phospho-C5AR1 - S338 Polyclonal Antibody
CAT# AFG-PAB-01776
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® C5AR1 Polyclonal Antibody
CAT# AFG-PAB-01775
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® C5AR1 Antibody (Phospho-Ser338)
CAT# AFG-IVA-04198
Size: 100 µg
Terminal: N/A
719.15 719.15 USD
AffiAB® C5ar1 Antibody - PE Conjugated
CAT# AFG-IVA-04197
Size: 100 Tests
Terminal: N/A
921.65 921.65 USD
AffiAB® C5AR1 Antibody - FITC Conjugated
CAT# AFG-IVA-04196
Size: 0.1 mg
Terminal: N/A
894.65 894.65 USD
AffiAB® C5ar1 Antibody - Biotin Conjugated
CAT# AFG-IVA-04195
Size: 0.1 mg
Terminal: N/A
786.65 786.65 USD
AffiAB® C5AR1 Antibody
CAT# AFG-IVA-04194
Size: 0.1 mg
Terminal: N/A
543.65 543.65 USD