ARMC Antibodies

ARMC antibodies are designed to target the Armadillo Repeat-Containing (ARMC) family of proteins, which are characterized by the presence of armadillo (ARM) repeats. These repeats are protein-protein interaction motifs that facilitate various cellular functions, including signal transduction, cell adhesion, cytoskeletal organization, and intracellular transport. ARMC proteins are involved in diverse biological processes, and dysregulation of these proteins has been linked to various conditions, including cancer, neurodevelopmental disorders, and ciliopathies. 

Content

The Armadillo (ARM) repeat is a structural motif composed of a series of tandemly repeated units, forming a superhelical structure that enables ARMC proteins to interact with multiple partners. These interactions allow ARMC proteins to participate in critical cellular processes, such as mediating cell-cell junctions, regulating the cytoskeleton, and modulating signaling pathways. 

Application

ARMC antibodies are widely used in several research applications, including:

• Immunofluorescence (IF): Allows for high-resolution visualization of ARMC proteins at the cellular level, showing their specific localization and interaction with other cellular structures, such as the cytoskeleton or cell membranes. IF is useful for studying the role of ARMC proteins in processes like cell adhesion, intracellular transport, and signaling pathways.
• Flow Cytometry: Applied to analyze ARMC protein expression on a per-cell basis, which helps in quantifying changes in response to external stimuli or during disease progression. Flow cytometry can be used to study ARMC proteins involved in immune signaling or cellular differentiation.
• Immunoprecipitation (IP): Used to isolate ARMC proteins from complex protein mixtures, facilitating the study of their interactions with other proteins. IP helps identify binding partners and explore the regulatory networks in which ARMC proteins participate, which is essential for understanding their function in processes such as cell signaling, migration, and structure maintenance.

These applications make ARMC antibodies crucial tools for advancing research on cellular dynamics and protein-protein interactions. By studying ARMC proteins, researchers can gain insights into the intricate networks that regulate cell behavior, which is particularly important for understanding how dysregulation of these proteins contributes to diseases, including cancer, ciliopathies, and neurological disorders.