ANGPTL Antibodies

ANGPTL (Angiopoietin-like) antibodies are used to detect and study the angiopoietin-like proteins, which are involved in various physiological processes, including angiogenesis, lipid metabolism, and inflammation. ANGPTL proteins share structural similarities with angiopoietins but have distinct functions.

Structure and Function of ANGPTL Proteins
  • Structure:
    • Domains: ANGPTL proteins typically contain an N-terminal coiled-coil domain, a central domain, and a C-terminal domain.
    • Glycosylation: Many ANGPTL proteins are glycosylated, which affects their stability and activity.
  • Functions:
    • Angiogenesis: Modulate blood vessel formation and endothelial cell function.
    • Lipid Metabolism: Regulate lipoprotein metabolism, often by inhibiting lipoprotein lipase (LPL) activity. For example, ANGPTL3 and ANGPTL4 are known inhibitors of LPL.
    • Inflammation: Influence inflammatory responses and metabolic processes.
Types of ANGPTL Proteins
  • ANGPTL1: Involved in angiogenesis and vascular remodeling.
  • ANGPTL2: Plays a role in inflammation and insulin resistance.
  • ANGPTL3: Regulates lipid metabolism by inhibiting LPL and is associated with lipid disorders.
  • ANGPTL4: Involved in lipid metabolism, particularly in adipose tissue and muscle, and regulates LPL activity.
  • ANGPTL5: Less well-characterized, but implicated in metabolic regulation.
  • ANGPTL6 (also known as angiopoietin-related growth factor, ARGF): Plays a role in metabolic regulation and tissue repair.
Applications of ANGPTL Antibodies
  • Western Blotting:
    • Purpose: Detect and quantify ANGPTL proteins in cell or tissue extracts.
    • Application: Study expression patterns, analyze protein modifications, and evaluate responses to treatments.
  • Immunohistochemistry (IHC):
    • Purpose: Localize ANGPTL proteins in tissue sections.
    • Application: Investigate tissue-specific distribution and subcellular localization in various tissues.
  • Immunoprecipitation (IP):
    • Purpose: Enrich ANGPTL proteins from cell lysates.
    • Application: Study protein-protein interactions and post-translational modifications.

ANGPTL (Angiopoietin-like) antibodies are used to detect and study the angiopoietin-like proteins, which are involved in various physiological processes, including angiogenesis, lipid metabolism, and inflammation. ANGPTL proteins share structural similarities with angiopoietins but have distinct functions.

Structure and Function of ANGPTL Proteins

  • Structure:
    • Domains: ANGPTL proteins typically contain an N-terminal coiled-coil domain, a central domain, and a C-terminal domain.
    • Glycosylation: Many ANGPTL proteins are glycosylated, which affects their stability and activity.
  • Functions:
    • Angiogenesis: Modulate blood vessel formation and endothelial cell function.
    • Lipid Metabolism: Regulate lipoprotein metabolism, often by inhibiting lipoprotein lipase (LPL) activity. For example, ANGPTL3 and ANGPTL4 are known inhibitors of LPL.
    • Inflammation: Influence inflammatory responses and metabolic processes.

Types of ANGPTL Proteins

  • ANGPTL1: Involved in angiogenesis and vascular remodeling.
  • ANGPTL2: Plays a role in inflammation and insulin resistance.
  • ANGPTL3: Regulates lipid metabolism by inhibiting LPL and is associated with lipid disorders.
  • ANGPTL4: Involved in lipid metabolism, particularly in adipose tissue and muscle, and regulates LPL activity.
  • ANGPTL5: Less well-characterized, but implicated in metabolic regulation.
  • ANGPTL6 (also known as angiopoietin-related growth factor, ARGF): Plays a role in metabolic regulation and tissue repair.

Applications of ANGPTL Antibodies

  • Western Blotting:
    • Purpose: Detect and quantify ANGPTL proteins in cell or tissue extracts.
    • Application: Study expression patterns, analyze protein modifications, and evaluate responses to treatments.
  • Immunohistochemistry (IHC):
    • Purpose: Localize ANGPTL proteins in tissue sections.
    • Application: Investigate tissue-specific distribution and subcellular localization in various tissues.
  • Immunoprecipitation (IP):
    • Purpose: Enrich ANGPTL proteins from cell lysates.
    • Application: Study protein-protein interactions and post-translational modifications.
  • Enzyme-Linked Immunosorbent Assay (ELISA):
    • Purpose: Quantify ANGPTL levels in serum or other biological fluids.
    • Application: Measure changes in ANGPTL expression and activity under different conditions and in disease states.
  • Flow Cytometry:
    • Purpose: Analyze ANGPTL expression on cell surfaces.
    • Application: Quantify surface expression and monitor changes in response to treatments.

Mechanism of Detection

  • Specificity: ANGPTL antibodies bind specifically to ANGPTL proteins, allowing for accurate detection.
  • Signal Detection: Methods such as chemiluminescence, fluorescence, or colorimetric assays are used to visualize antibody binding in various assay formats.

Advantages of Using ANGPTL Antibodies

  • High Specificity: Ensures accurate detection of ANGPTL proteins with minimal cross-reactivity.
  • Versatility: Suitable for multiple techniques including Western blotting, IHC, IP, ELISA, and flow cytometry.
  • Sensitivity: Allows for the detection of ANGPTL proteins even at low concentrations in complex samples.

AffiAB® Rabbit Anti-ANGPTL3 Antibody
CAT# AFG-DDA-7244
Size: 100 μL
319.20 319.2 USD
AffiAB® Rabbit Anti-ANGPTL7 Antibody
CAT# AFG-DDA-6383
Size: 100 μL
317.30 317.3 USD
AffiAB® Rabbit anti-ANGPTL1 Antibody
CAT# AFG-DDA-2866
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-ANGPTL1 Antibody
CAT# AFG-DDA-1924
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-ANGPTL1 Antibody
CAT# AFG-DDA-1257
Size: 100 μL
274.55 274.55 USD
AffiAB® Rabbit anti-ANGPTL4 Antibody
CAT# AFG-DDA-0151
Size: 100 μL
256.50 256.5 USD
AffiAB® ANGPTL8 Polyclonal Antibody
CAT# AFG-PAB-00687
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® ANGPTL7 Polyclonal Antibody
CAT# AFG-PAB-00686
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® ANGPTL5 Polyclonal Antibody
CAT# AFG-PAB-00685
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® ANGPTL4 Polyclonal Antibody
CAT# AFG-PAB-00684
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® ANGPTL3 Polyclonal Antibody
CAT# AFG-PAB-00683
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® ANGPTL2 Polyclonal Antibody
CAT# AFG-PAB-00682
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® ANGPTL1 Polyclonal Antibody
CAT# AFG-PAB-00681
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® Rabbit anti-ANGPTL7 Antibody
CAT# AFG-YBP-0633
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-ANGPTL4 Antibody
CAT# AFG-YBP-0632
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-ANGPTL3 Antibody
CAT# AFG-YBP-0631
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-ANGPTL1 Antibody
CAT# AFG-YBP-0630
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-ANGPTL1 Antibody
CAT# AFG-YBP-0629
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-ANGPTL1 Antibody
CAT# AFG-YBP-0628
Size: 100 µL
457.00 457.0 USD
AffiAB® ANGPTL8 Antibody
CAT# AFG-IVA-01114
Size: 100 µg
Terminal: N/A
705.65 705.65 USD
AffiAB® ANGPTL7 Antibody
CAT# AFG-IVA-01113
Size: 100 µL
Terminal: N/A
570.65 570.65 USD
AffiAB® ANGPTL6 Antibody
CAT# AFG-IVA-01112
Size: 25 µL
Terminal: C-terminal region
378.95 378.95 USD
AffiAB® ANGPTL5 Antibody
CAT# AFG-IVA-01111
Size: 100 µL
Terminal: N/A
557.15 557.15 USD
AffiAB® ANGPTL4 Antibody
CAT# AFG-IVA-01110
Size: 100 µL
Terminal: N/A
705.65 705.65 USD
AffiAB® Angptl3 Antibody-N-terminal region
CAT# AFG-IVA-01109
Size: 100 µL
Terminal: N/A
683.45 683.45 USD
AffiAB® ANGPTL3 Antibody
CAT# AFG-IVA-01108
Size: 100 µg
Terminal: N/A
705.65 705.65 USD
AffiAB® ANGPTL2 Antibody
CAT# AFG-IVA-01107
Size: 100 µg
Terminal: N/A
705.65 705.65 USD
AffiAB® ANGPTL1 Antibody
CAT# AFG-IVA-01106
Size: 100 µg
Terminal: N/A
705.65 705.65 USD
AffiAB® Angptl7 Rabbit Polyclonal Antibody
CAT# AFG-EKA-03946
Size: 100 µL
246.00 246.0 USD
AffiAB® Angptl1 Rabbit Polyclonal Antibody
CAT# AFG-EKA-03599
Size: 100 µL
246.00 246.0 USD
AffiAB® Angptl1/2 Rabbit Polyclonal Antibody
CAT# AFG-EKA-03422
Size: 100 µL
246.00 246.0 USD
AffiAB® Angptl4 Rabbit Polyclonal Antibody
CAT# AFG-EKA-03409
Size: 100 µL
246.00 246.0 USD
AffiAB® Angptl1 Rabbit Polyclonal Antibody
CAT# AFG-EKA-03278
Size: 100 µL
246.00 246.0 USD