AGTR2 Antibodies

AGTR2 antibodies are designed to specifically target the Angiotensin II Receptor Type 2 (AGTR2), a G-protein-coupled receptor (GPCR) that mediates the effects of angiotensin II, a key regulator of blood pressure and fluid balance. Unlike the Type 1 receptor (AGTR1), which promotes vasoconstriction, AGTR2 generally counteracts these effects by inducing vasodilation, anti-inflammatory responses, and cell differentiation.

Content

AGTR2 plays a complex role in the renin-angiotensin system (RAS), primarily acting as a modulator that balances the vasoconstrictive effects of AGTR1. When activated by angiotensin II, AGTR2 triggers signaling pathways that promote vasodilation, inhibit cell proliferation, and reduce oxidative stress, contributing to protective cardiovascular effects. It is also involved in neurodevelopment, tissue repair, and anti-inflammatory processes. 

Application

AGTR2 antibodies are widely used in multiple research applications, including:

• Immunofluorescence (IF): Allows for detailed observation of AGTR2 at the cellular level, offering insights into its subcellular localization, receptor trafficking, and interaction with other signaling molecules. IF is useful for studying how AGTR2 modulates responses to angiotensin II and how this regulation is altered in disease models.
• Flow Cytometry: Used to analyze AGTR2 expression on the surface of various cell types, including endothelial cells, neurons, and cardiac cells. Flow cytometry can assess receptor density, enabling research into the effects of agonists, antagonists, and other modulators on AGTR2 function.
• Immunoprecipitation (IP): Applied to isolate AGTR2 from complex protein mixtures, enabling the study of its interactions with downstream signaling molecules, such as phosphatases, kinases, and other receptors. IP helps understand how AGTR2 signaling is integrated within broader cellular pathways and how it may be targeted for therapeutic intervention.

These applications make AGTR2 antibodies crucial tools for advancing research on the physiological and pathological roles of the Angiotensin II Receptor Type 2. They support the investigation of AGTR2’s protective effects in cardiovascular and neurovascular systems, providing insights into therapeutic strategies for managing conditions like hypertension, heart failure, and neurodegenerative disorders.