TNFRSF Antibodies

Tumor Necrosis Factor Receptor Superfamily (TNFRSF) comprises a group of receptors that bind tumor necrosis factors (TNF), playing a key role in regulating immune responses, inflammation, apoptosis, and cell survival. Members of the TNFRSF include TNFR1 (TNFRSF1A), TNFR2 (TNFRSF1B), CD40 (TNFRSF5), Fas (TNFRSF6), and DR4/DR5 (TNFRSF10A/B), among others. 

Technical Specifications

• Host Species: TNFRSF antibodies are commonly produced in hosts such as rabbits, mice, or goats. Recombinant monoclonal antibodies are also available for enhanced specificity and reproducibility.
• Clonality: Both monoclonal and polyclonal TNFRSF antibodies are available. Monoclonal antibodies bind to a specific epitope on the receptor, offering high specificity, while polyclonal antibodies recognize multiple epitopes, increasing sensitivity.
• Isotypes: TNFRSF antibodies are typically of the IgG isotype, ensuring compatibility with various secondary antibodies and detection reagents.

Molecular Applications of TNFRSF Antibodies

• Immune Regulation and Inflammation: TNFRSF members like TNFR1 (TNFRSF1A) and TNFR2 (TNFRSF1B) mediate inflammatory responses and immune cell activation. TNFRSF antibodies are employed to study how these receptors regulate immune responses during infections, autoimmune diseases, and chronic inflammation. For example, TNFR1 antibodies are widely used in studying TNF-mediated inflammation in conditions like rheumatoid arthritis and Crohn's disease.
• Cancer Research: CD40 (TNFRSF5) and other TNFRSF members play roles in immune cell activation and tumor immunity. CD40 antibodies are used to explore its role in enhancing the immune response against tumors and as a potential therapeutic target in cancer immunotherapy.
• Cell Survival and Proliferation: TNFRSF members are also involved in cell survival and proliferation. For instance, TNFR2 is known to promote cell survival in certain contexts, such as in regulatory T cells (Tregs). TNFR2 antibodies help researchers study its role in maintaining immune homeostasis and its potential as a therapeutic target in immunological diseases and cancer.

TNFRSF antibodies are invaluable tools for studying the diverse biological roles of TNFRSF receptors in immune regulation, inflammation, apoptosis, and cancer. These antibodies allow researchers to investigate receptor-ligand interactions, signal transduction pathways, and the role of TNFRSF members in both health and disease. Additionally, TNFRSF antibodies have important therapeutic applications, particularly in targeting dysregulated TNFRSF signaling in autoimmune diseases and cancer.