SNAP Antibodies

Function and Importance of SNAP Antibodies: SNAP antibodies are used to detect and quantify specific SNAP proteins in biological samples, providing researchers with the ability to explore how these proteins mediate membrane fusion events. SNAP proteins work in concert with NSF (N-ethylmaleimide-sensitive factor) and SNARE proteins to regulate exocytosis, endocytosis, and intracellular vesicle transport. 

Applications of SNAP antibodies include:

  • Western Blot (WB): Used to detect SNAP proteins in cell or tissue lysates, enabling quantitative analysis of their expression under different conditions or during various stages of vesicle trafficking.
  • Immunoprecipitation (IP): Facilitates the isolation of SNAP-containing protein complexes, allowing researchers to study protein-protein interactions involved in membrane fusion and vesicular transport.
  • Immunofluorescence (IF) and Immunohistochemistry (IHC): These techniques are employed to visualize the subcellular localization of SNAP proteins, particularly at synapses, plasma membranes, and other vesicle fusion sites in neuronal and endocrine cells.
  • Flow Cytometry (FACS): Applied to assess the surface expression of SNAP proteins, particularly in cells involved in secretion and neurotransmitter release.

SNAP Antibody Applications in Research:

  • Neurobiology and Synaptic Transmission: SNAP-25 antibodies are widely used in neurobiological research to study synaptic vesicle fusion and neurotransmitter release. These antibodies help researchers investigate the molecular mechanisms underlying synaptic plasticity, learning, memory, and neurological disorders.
  • Endocrinology and Secretion: SNAP-23 antibodies are essential for studying hormone secretion, particularly in pancreatic beta cells (insulin release) and immune cells (degranulation). Researchers use these antibodies to explore the role of SNAP-23 in metabolic diseases like diabetes.
  • Cancer and Immune Responses: SNAP antibodies, particularly those targeting SNAP-23, are used to study immune cell degranulation and the role of vesicle fusion in immune surveillance and response. Dysregulation of these processes can have implications in cancer biology and immune disorders.

SNAP antibodies are powerful tools for studying the molecular mechanisms of membrane fusion, vesicle trafficking, and secretion. By targeting specific SNAP proteins, researchers can investigate their roles in fundamental cellular processes, such as neurotransmitter release, hormone secretion, and intracellular vesicle dynamics. These antibodies are particularly valuable in research focused on neurological diseases, metabolic disorders, immune responses, and autophagy.

AffiAB® Rabbit Anti-SNAP25 Antibody
CAT# AFG-DDA-7569
Size: 100 μL
324.90 324.90000000000003 USD
AffiAB® Rabbit Anti-SNAP29 Antibody
CAT# AFG-DDA-6048
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit Anti-SNAP-gamma Antibody
CAT# AFG-DDA-5704
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit anti-Snapin Antibody
CAT# AFG-DDA-3396
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-SNAP-alpha Antibody
CAT# AFG-DDA-3152
Size: 100 μL
284.05 284.05 USD
AffiAB® SNAPIN Polyclonal Antibody
CAT# AFG-PAB-14302
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® SNAP91 Polyclonal Antibody
CAT# AFG-PAB-14299
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® SNAP29 Polyclonal Antibody
CAT# AFG-PAB-14298
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® SNAP25 Polyclonal Antibody
CAT# AFG-PAB-14297
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® SNAP23 Polyclonal Antibody
CAT# AFG-PAB-14296
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® NIPSNAP3B Polyclonal Antibody
CAT# AFG-PAB-10159
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® NIPSNAP3A Polyclonal Antibody
CAT# AFG-PAB-10158
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® Rabbit anti-Snapin Antibody
CAT# AFG-YBP-7486
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-SNAP-gamma Antibody
CAT# AFG-YBP-7485
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-SNAP-alpha Antibody
CAT# AFG-YBP-7484
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-SNAP29 Antibody
CAT# AFG-YBP-7483
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-SNAP25 Antibody
CAT# AFG-YBP-7482
Size: 100 µL
457.00 457.0 USD
AffiAB® Anti-SNAP23 Antibody [JA73-15]
CAT# AFG-HB-3631
Size: 100 μL
496.50 496.5 USD