RMB Antibodies

RBM (RNA Binding Motif) antibodies are designed to target proteins in the RNA Binding Motif (RBM) family, which are crucial for RNA processing, including splicing, transport, stabilization, and translation regulation. RBM proteins play a significant role in post-transcriptional regulation of gene expression, ensuring that RNA molecules are properly processed and function in the correct cellular context. 

Applications of RBM Antibodies
  • Western Blotting (WB): RBM antibodies are used to detect and quantify RBM protein levels in cell and tissue lysates. This is particularly useful for monitoring changes in RBM expression during different cellular conditions, such as stress, differentiation, or disease states like cancer.
  • Immunohistochemistry (IHC): RBM antibodies are applied to tissue sections to visualize RBM protein expression and localization in various tissues. This is useful in studying RBM protein dysregulation in diseases such as cancer and neurodegenerative disorders.
  • Flow Cytometry (FC): RBM antibodies can be used in flow cytometry to analyze RBM expression in different cell populations, particularly in studies of cancer cells or stem cells, where RBM protein expression may correlate with differentiation or tumor progression.
RBM Antibodies in Disease Research
  • Cancer: RBM proteins, particularly RBM5, RBM6, and RBM10, have been implicated in cancer, where they regulate alternative splicing events critical for tumor progression and metastasis. RBM5, for instance, is considered a tumor suppressor, and its loss is associated with the development of lung cancer. RBM antibodies are used to study how these proteins regulate splicing and their impact on tumorigenesis, cell survival, and response to therapy.
  • Muscular Dystrophies: Certain RBM proteins are involved in regulating the splicing of transcripts critical for muscle function. Dysregulation of these splicing events can lead to diseases such as myotonic dystrophy. RBM antibodies help investigate the role of RNA processing defects in these disorders.
  • Stress Response and Cell Differentiation: RBM proteins like RBM3 and RBM10 are involved in cellular responses to stress and differentiation processes. RBM3, for example, is upregulated under hypoxic or cold stress conditions and plays a role in the global reduction of translation to protect cells from damage. RBM antibodies are used to study how these proteins mediate the stress response and influence cell fate decisions.

RBM antibodies are essential tools for studying the molecular mechanisms underlying RNA processing, splicing regulation, and RNA stability. They are particularly valuable in research related to cancer, neurodegenerative diseases, and muscular dystrophies, where dysregulated RNA metabolism plays a significant role in disease progression.

AffiAB® Rabbit anti-RBM17 Antibody
CAT# AFG-DDA-3606
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-RBM6 Antibody
CAT# AFG-DDA-3415
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-RBM26 Antibody
CAT# AFG-DDA-2656
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-RBM34 Antibody
CAT# AFG-DDA-1982
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit anti-RBM3 Antibody
CAT# AFG-DDA-1566
Size: 100 μL
274.55 274.55 USD
AffiAB® Rabbit anti-RBM22 Antibody
CAT# AFG-DDA-1445
Size: 100 μL
274.55 274.55 USD
AffiAB® RBMY1F Polyclonal Antibody
CAT# AFG-PAB-12759
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® RBMY1A1 Polyclonal Antibody
CAT# AFG-PAB-12758
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® RBMX2 Polyclonal Antibody
CAT# AFG-PAB-12757
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBMX Polyclonal Antibody
CAT# AFG-PAB-12756
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® RBMS3 Polyclonal Antibody
CAT# AFG-PAB-12755
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® RBMS2 Polyclonal Antibody
CAT# AFG-PAB-12754
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBMS1 Polyclonal Antibody
CAT# AFG-PAB-12753
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM8A Polyclonal Antibody
CAT# AFG-PAB-12752
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM7 Polyclonal Antibody
CAT# AFG-PAB-12751
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® RBM6 Polyclonal Antibody
CAT# AFG-PAB-12750
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® RBM5 Polyclonal Antibody
CAT# AFG-PAB-12749
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® RBM4B Polyclonal Antibody
CAT# AFG-PAB-12748
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® rbm47 Polyclonal Antibody
CAT# AFG-PAB-12747
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® RBM45 Polyclonal Antibody
CAT# AFG-PAB-12746
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® RBM42 Polyclonal Antibody
CAT# AFG-PAB-12745
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM41 Polyclonal Antibody
CAT# AFG-PAB-12744
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM4 Polyclonal Antibody
CAT# AFG-PAB-12743
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM39 Polyclonal Antibody
CAT# AFG-PAB-12742
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM38 Polyclonal Antibody
CAT# AFG-PAB-12741
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® RBM34 Polyclonal Antibody
CAT# AFG-PAB-12740
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® RBM3 Polyclonal Antibody
CAT# AFG-PAB-12739
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM28 Polyclonal Antibody
CAT# AFG-PAB-12738
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM26 Polyclonal Antibody
CAT# AFG-PAB-12737
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® rbm24 Polyclonal Antibody
CAT# AFG-PAB-12736
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® RBM22 Polyclonal Antibody
CAT# AFG-PAB-12735
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® RBM19 Polyclonal Antibody
CAT# AFG-PAB-12734
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM17 Polyclonal Antibody
CAT# AFG-PAB-12733
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM15 Polyclonal Antibody
CAT# AFG-PAB-12732
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM14 Polyclonal Antibody
CAT# AFG-PAB-12731
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM12B Polyclonal Antibody
CAT# AFG-PAB-12730
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® RBM12 Polyclonal Antibody
CAT# AFG-PAB-12729
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® RBM11 Polyclonal Antibody
CAT# AFG-PAB-12728
Size: 100 µg
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® RBM10 Polyclonal Antibody
CAT# AFG-PAB-12727
Size: 150 µL
Conjugation: Unconjugated
1,112.50 1112.5 USD
AffiAB® Rabbit anti-RBM6 Antibody
CAT# AFG-YBP-6887
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-RBM34 Antibody
CAT# AFG-YBP-6886
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-RBM3 Antibody
CAT# AFG-YBP-6885
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-RBM26 Antibody
CAT# AFG-YBP-6884
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-RBM22 Antibody
CAT# AFG-YBP-6883
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-RBM17 Antibody
CAT# AFG-YBP-6882
Size: 100 µL
457.00 457.0 USD
AffiAB® Anti-RBM3 Antibody [JE63-84]
CAT# AFG-HB-3383
Size: 100 μL
496.50 496.5 USD
AffiAB® RBM10 Rabbit Polyclonal Antibody
CAT# AFG-EKA-11471
Size: 100 µL
246.00 246.0 USD
AffiAB® RBMS1 Rabbit Polyclonal Antibody
CAT# AFG-EKA-11440
Size: 100 µL
246.00 246.0 USD
AffiAB® RBMS3 Rabbit Polyclonal Antibody
CAT# AFG-EKA-11361
Size: 100 µL
246.00 246.0 USD
AffiAB® RBM26 Rabbit Polyclonal Antibody
CAT# AFG-EKA-06651
Size: 100 µL
246.00 246.0 USD
AffiAB® RBM34 Rabbit Polyclonal Antibody
CAT# AFG-EKA-04798
Size: 100 µL
246.00 246.0 USD
AffiAB® RBM16 Rabbit Polyclonal Antibody
CAT# AFG-EKA-04762
Size: 100 µL
246.00 246.0 USD