GNG Antibodies

GNG (Guanine Nucleotide-Binding Protein Subunit Gamma) is a component of the heterotrimeric G-protein complex, which is involved in transmitting signals from G-protein-coupled receptors (GPCRs) to intracellular signaling pathways. GNG proteins play an essential role in various physiological processes, including cell proliferation, differentiation, and metabolic regulation. The G-protein complex consists of three subunits: alpha (Gα), beta (Gβ), and gamma (Gγ), with GNG being the gamma subunit, which partners with Gβ to regulate the activity of Gα and its downstream effectors.

Content

GNG antibodies are developed to specifically recognize GNG proteins, allowing for the detection and study of their role in GPCR-mediated signaling pathways. These antibodies are widely used in immunohistochemistry (IHC), Western blotting, immunoprecipitation (IP), ELISA, and flow cytometry to assess GNG expression, localization, and function in cells and tissues.

Applications

• GPCR Signaling Research: GNG proteins are integral to GPCR-mediated signaling, which is involved in regulating cellular responses to external stimuli. GNG antibodies are used to investigate the interactions between G-protein subunits and GPCRs, as well as the downstream signaling pathways they activate. This is particularly relevant in studies focused on signal transduction, where GNG proteins play a role in modulating receptor sensitivity and effector activation.
• Cancer Research: G-proteins, including GNG subunits, are involved in regulating cell proliferation and survival. Dysregulation of GNG expression or function has been linked to various cancers. GNG antibodies are used to examine the role of GNG in tumor growth, metastasis, and cancer cell signaling, providing insights into how G-protein signaling is altered in oncogenic pathways.
• Cardiovascular Research: GNG proteins play a role in regulating cardiovascular function by mediating the effects of GPCRs involved in blood pressure regulation, heart rate, and vascular tone. GNG antibodies are used to explore the mechanisms by which G-protein signaling affects cardiovascular health and how dysregulation of these pathways contributes to hypertension, heart failure, and other cardiovascular diseases.
• Pharmacological Targeting: Given the central role of GPCRs in mediating physiological responses, GNG proteins are targets for drug development. GNG antibodies are utilized in studies assessing the effects of drugs that modulate GPCR signaling, allowing researchers to evaluate the impact of pharmacological agents on G-protein activity and related signaling pathways.

By employing GNG antibodies, researchers can dissect the role of G-proteins in various signaling networks, offering valuable insights into their involvement in health and disease, particularly in cancer, neuroscience, and cardiovascular research.