DPYSL Antibodies

DPYSL (Dihydropyrimidinase-like) proteins, also known as CRMP (Collapsin Response Mediator Proteins), are involved in axonal growth, neuronal differentiation, and guidance during development. DPYSL proteins (such as DPYSL2/CRMP2, DPYSL3/CRMP4, and others) regulate microtubule dynamics, contributing to the stabilization and organization of the cytoskeleton in neurons. 

Content on DPYSL Antibodies

DPYSL antibodies target specific isoforms of DPYSL proteins, such as DPYSL2 (CRMP2), which is heavily involved in neuronal development and axonal outgrowth. These antibodies are used in various research applications, including Western blotting, immunoprecipitation, immunohistochemistry, and immunofluorescence to examine the localization, expression, and post-translational modifications of DPYSL proteins.

Applications of DPYSL Antibodies

• Neurodegenerative Diseases: Phosphorylated forms of DPYSL proteins, particularly DPYSL2, are associated with neurodegenerative diseases such as Alzheimer’s disease and amyotrophic lateral sclerosis (ALS). DPYSL antibodies are employed to investigate the accumulation of phosphorylated DPYSL proteins in diseased neurons, offering insights into how dysregulated microtubule dynamics contribute to neurodegeneration and axonal degeneration.
• Cancer Research: Dysregulated expression of DPYSL proteins has been observed in certain cancers, particularly in tumors involving the nervous system. DPYSL antibodies are used to study the role of these proteins in cancer cell migration, invasion, and metastasis. By analyzing DPYSL expression in cancerous tissues, researchers can investigate how changes in cytoskeletal organization and cell motility contribute to tumor progression.
• Molecular Mechanisms of Axonal Degeneration: Axonal degeneration is a hallmark of many neurodegenerative diseases, and DPYSL proteins are directly involved in this process. DPYSL antibodies are used to investigate the mechanisms leading to axonal collapse and degeneration, particularly focusing on how DPYSL phosphorylation affects microtubule stability. This has implications for the development of therapeutic strategies aimed at preventing or slowing axonal loss in diseases like Alzheimer’s and Parkinson’s.

In conclusion, DPYSL antibodies are essential for studying neuronal development, axonal guidance, neurodegeneration, and cancer cell dynamics. Their use in research applications provides detailed insights into how DPYSL proteins regulate cytoskeletal organization, neuronal connectivity, and disease progression, making them critical tools in neurobiology and disease-related studies.