DLG1 Antibodies

DLG1 (Discs Large Homolog 1), also known as SAP97 (Synapse-Associated Protein 97), is a member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins. DLG1 is involved in maintaining cell polarity, regulating signal transduction, and organizing multiprotein complexes at synaptic and epithelial junctions. 

Content on DLG1 Antibodies

DLG1 antibodies specifically target the DLG1 protein, allowing researchers to investigate its distribution and function in cellular processes such as junction formation, signaling, and maintenance of epithelial integrity. These antibodies are employed in techniques like Western blotting, immunofluorescence, immunohistochemistry, and immunoprecipitation to analyze DLG1 expression and interaction with other proteins.

Applications of DLG1 Antibodies

• Cancer Research: DLG1 is a tumor suppressor that regulates cell proliferation and epithelial cell polarity. In many cancers, the loss or dysfunction of DLG1 is associated with the disruption of cell polarity and increased tumorigenic potential. DLG1 antibodies are used to study the role of DLG1 in tumor progression, particularly in epithelial cancers, by analyzing how its expression or localization is altered during cancer development.
• Cell Polarity and Junction Formation: DLG1 plays a crucial role in maintaining the apical-basal polarity of epithelial cells by regulating tight junctions and adherens junctions. DLG1 antibodies are essential tools for studying how epithelial cells establish and maintain polarity and how disruptions in DLG1 contribute to diseases characterized by loss of cell junction integrity, such as inflammatory bowel disease (IBD) or epithelial barrier dysfunctions.
• Neurobiology and Synaptic Function: In neurons, DLG1 is involved in organizing synaptic signaling complexes. DLG1 antibodies are used in neurobiology research to explore its role in synaptic plasticity and the regulation of ion channels and neurotransmitter receptors. Dysregulation of DLG1 has been linked to neurodevelopmental disorders and cognitive dysfunction, making these antibodies valuable for studying synaptic architecture and function.
• Cell Signaling Pathways: DLG1 interacts with various signaling molecules and pathways, including those involved in cell growth, differentiation, and apoptosis. DLG1 antibodies are used to investigate how this scaffolding protein influences signaling pathways, such as the Hippo signaling pathway, which controls organ size and tumorigenesis by regulating cell proliferation and apoptosis.

In conclusion, DLG1 antibodies are crucial for studying cell polarity, junction formation, and signaling in both epithelial and neuronal tissues. Their applications span cancer research, neurobiology, developmental biology, and immunological studies, making them valuable tools for understanding the molecular mechanisms that maintain cellular integrity and function.