COL11A1 Antibodies

COL11A1 antibodies target the COL11A1 protein, a subunit of type XI collagen, which plays a critical role in the formation of collagen fibrils in cartilage and other connective tissues. Type XI collagen is a minor fibrillar collagen involved in regulating fibril diameter and spacing, essential for maintaining the structural integrity of cartilage and other extracellular matrix (ECM) components. 

Content of COL11A1 Antibodies

COL11A1 antibodies are typically monoclonal or polyclonal antibodies developed to specifically recognize the COL11A1 protein in tissue samples and cell lysates. These antibodies are widely used in research applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and enzyme-linked immunosorbent assays (ELISA) to study the expression, localization, and function of COL11A1 in both normal and pathological conditions.

• COL11A1: Involved in the formation and organization of cartilage matrix, as well as in maintaining the structure of other connective tissues. It plays a role in the assembly of the extracellular matrix and the regulation of fibril formation.

Application of COL11A1 Antibodies

• Connective Tissue Disorder Research: COL11A1 antibodies are used to study disorders of the connective tissue, particularly those involving cartilage defects, such as Stickler syndrome and Marshall syndrome. By detecting COL11A1 in cartilage and other connective tissues, researchers can explore the molecular mechanisms that lead to the abnormal structure and function of collagen in these disorders.
• Cancer Research: COL11A1 has been identified as a marker for tumor progression, particularly in cancers such as pancreatic, ovarian, and breast cancers. COL11A1 antibodies are employed in cancer research to study its overexpression in the tumor microenvironment, where it is associated with increased tumor invasiveness and poor prognosis. These antibodies help investigate how COL11A1 contributes to tumor-stromal interactions and ECM remodeling in cancer progression.
• Cartilage and ECM Biology: Since COL11A1 is integral to the structure of cartilage and ECM, COL11A1 antibodies are used in studies of cartilage development, tissue engineering, and ECM-related processes. Researchers use these antibodies to examine how COL11A1 interacts with other collagen types (such as type II collagen) to maintain the integrity of cartilage and to investigate its role in cartilage-related diseases such as osteoarthritis.
• Immunohistochemistry and Immunofluorescence: COL11A1 antibodies are applied in IHC and IF to visualize the localization and distribution of COL11A1 in tissues. These techniques are used to assess COL11A1 expression in normal and diseased tissues, particularly in studies focused on cartilage development and cancer progression.

COL11A1 antibodies are essential tools for understanding the molecular mechanisms underlying connective tissue disorders, cancer progression, cartilage biology, and tissue remodeling. They are widely used in both basic research and clinical studies related to collagen-associated diseases.