ARL Antibodies

CoA antibodies are developed to target Coenzyme A (CoA) or proteins associated with CoA metabolism. CoA is a critical cofactor involved in numerous biochemical reactions, particularly in energy metabolism, fatty acid synthesis, and the citric acid cycle. CoA and its derivatives are vital for acetylation processes and the production of energy within cells. 

Content of CoA Antibodies

CoA antibodies can either be specific to CoA derivatives (such as acetyl-CoA) or to enzymes involved in CoA metabolism, such as acetyl-CoA synthetase, acetyl-CoA carboxylase, and pantothenate kinase. These antibodies are used in applications like Western blotting, immunoprecipitation, enzyme-linked immunosorbent assays (ELISA), and immunofluorescence (IF) to study CoA-related pathways and the regulation of energy metabolism.

• Acetyl-CoA: Central to cellular metabolism, involved in energy production via the citric acid cycle and in lipid biosynthesis.
• Pantothenate Kinase: Key enzyme in CoA biosynthesis, converting pantothenate (vitamin B5) to CoA.

Application of CoA Antibodies

• Metabolic Pathway Studies: CoA antibodies are used to study metabolic pathways involving CoA, such as fatty acid synthesis, oxidation, and the citric acid cycle. By targeting enzymes or CoA derivatives, researchers can investigate how CoA influences energy metabolism and lipid production in cells.
• Cellular Energy Regulation: CoA antibodies are crucial in examining how CoA and its derivatives regulate cellular energy homeostasis. These antibodies allow for the detection and quantification of CoA levels or its associated enzymes in tissues, providing insights into how energy production and consumption are balanced in different physiological states.
• Lipid Biosynthesis Research: Acetyl-CoA is a precursor for fatty acid synthesis, and antibodies targeting acetyl-CoA or acetyl-CoA carboxylase are used to study lipid biosynthesis. These antibodies help explore how lipid metabolism is regulated, particularly in contexts like obesity, diabetes, and cardiovascular diseases.
• Neurodegenerative Disease Research: Dysregulation of CoA metabolism has been implicated in neurodegenerative diseases such as pantothenate kinase-associated neurodegeneration (PKAN). CoA antibodies, especially those targeting enzymes like pantothenate kinase, are used in research to investigate how disruptions in CoA biosynthesis contribute to neuronal degeneration and metabolic dysfunction.

CoA antibodies are essential tools for understanding the role of CoA in energy metabolism, lipid biosynthesis, and disease, particularly in metabolic disorders and neurodegenerative diseases.