CACNG Antibodies

CACNG antibodies target the gamma subunit of voltage-dependent calcium channels, specifically from the CACNG family, which includes eight known subunits (CACNG1 through CACNG8). These subunits play a critical role in modulating the activity and biophysical properties of calcium channels, particularly in the context of excitatory synaptic transmission. CACNG proteins are involved in the stabilization and regulation of the calcium channel complex, influencing channel gating, trafficking, and voltage sensitivity. Dysregulation of CACNG proteins is linked to various neurological disorders, including epilepsy and myasthenia gravis.

Application of CACNG Antibodies
  • Immunofluorescence (IF): CACNG antibodies are employed in IF studies to visualize the subcellular localization of gamma subunits in neurons or muscle cells. This is essential for understanding how CACNG subunits influence calcium channel trafficking and function at synapses. IF with CACNG antibodies provides insights into the cellular and molecular mechanisms regulating calcium homeostasis in excitatory synapses.
  • Flow Cytometry (FACS): Fluorophore-conjugated CACNG antibodies are used in flow cytometry to quantify the expression of CACNG subunits in different cell populations. This application is valuable for studying calcium channel regulation in various tissues, including neurons, cardiomyocytes, and skeletal muscle cells. Flow cytometry with CACNG antibodies is particularly useful in high-throughput analyses of genetic models with altered calcium channel function.
  • Co-Immunoprecipitation (Co-IP): CACNG antibodies are used in Co-IP assays to investigate protein-protein interactions involving CACNG subunits and other calcium channel components. This application helps elucidate how CACNG subunits interact with other regulatory proteins and influence calcium channel assembly and stability. Co-IP studies with CACNG antibodies are essential for understanding the molecular dynamics of voltage-gated calcium channels.
  • Enzyme-Linked Immunosorbent Assay (ELISA): ELISA-based applications using CACNG antibodies allow for the quantification of CACNG subunit expression levels in cell lysates or biological fluids. This method is useful for assessing changes in CACNG protein levels under various conditions, including disease models where calcium channel dysfunction is a contributing factor.
Technical Specifications
  • Clonality: Monoclonal or Polyclonal
  • Isotype: IgG (species-specific variants)
  • Species Reactivity: Human, Mouse, Rat, and others depending on the specific antibody
  • Applications: WB, IHC, IF, FACS, Co-IP, ELISA
  • Isoform Specificity: Available for specific CACNG subunits (e.g., CACNG1, CACNG2)
AffiAB® Rabbit anti-CACNG8 Antibody
CAT# AFG-DDA-9127
Size: 100 μL
284.05 284.05 USD
AffiAB® Rabbit Anti-CACNG1 Antibody
CAT# AFG-DDA-6959
Size: 100 μL
319.20 319.2 USD
AffiAB® Rabbit Anti-CACNG5 Antibody
CAT# AFG-DDA-5435
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit Anti-CACNG4 Antibody
CAT# AFG-DDA-5434
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit Anti-CACNG3 Antibody
CAT# AFG-DDA-5433
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit Anti-CACNG2 Antibody
CAT# AFG-DDA-5432
Size: 100 μL
308.75 308.75 USD
AffiAB® Rabbit Anti-CACNG7 Antibody
CAT# AFG-DDA-4371
Size: 100 μL
300.20 300.2 USD
AffiAB® Rabbit anti-CACNG5 Antibody
CAT# AFG-DDA-2640
Size: 100 μL
284.05 284.05 USD
AffiAB® CACNG8 Polyclonal Antibody
CAT# AFG-PAB-01857
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® CACNG7 Polyclonal Antibody
CAT# AFG-PAB-01856
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® CACNG6 Polyclonal Antibody
CAT# AFG-PAB-01855
Size: 100 µL
Conjugation: Unconjugated
533.50 533.5 USD
AffiAB® CACNG5 Polyclonal Antibody
CAT# AFG-PAB-01854
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® CACNG4 Polyclonal Antibody
CAT# AFG-PAB-01853
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® CACNG3 Polyclonal Antibody
CAT# AFG-PAB-01852
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® CACNG2 Polyclonal Antibody
CAT# AFG-PAB-01851
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® CACNG1 Polyclonal Antibody
CAT# AFG-PAB-01850
Size: 100 µg
Conjugation: Unconjugated
335.50 335.5 USD
AffiAB® Rabbit anti-CACNG7 Antibody
CAT# AFG-YBP-1243
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-CACNG5 Antibody
CAT# AFG-YBP-1242
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-CACNG5 Antibody
CAT# AFG-YBP-1241
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-CACNG4 Antibody
CAT# AFG-YBP-1240
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-CACNG3 Antibody
CAT# AFG-YBP-1239
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-CACNG2 Antibody
CAT# AFG-YBP-1238
Size: 100 µL
457.00 457.0 USD
AffiAB® Rabbit anti-CACNG1 Antibody
CAT# AFG-YBP-1237
Size: 100 µL
457.00 457.0 USD
AffiAB® Cacng8 Antibody
CAT# AFG-IVA-04400
Size: 25 µL
Terminal: Middle region
378.95 378.95 USD
AffiAB® CACNG7 Antibody
CAT# AFG-IVA-04399
Size: 100 µg
Terminal: N/A
719.15 719.15 USD
AffiAB® CACNG6 Antibody
CAT# AFG-IVA-04398
Size: 25 µL
Terminal: N-terminal region
378.95 378.95 USD
AffiAB® CACNG5 antibody
CAT# AFG-IVA-04397
Size: 100 µL
Terminal: N/A
773.15 773.15 USD
AffiAB® CACNG4 Antibody
CAT# AFG-IVA-04396
Size: 100 µL
Terminal: N/A
597.65 597.65 USD
AffiAB® CACNG3 Antibody
CAT# AFG-IVA-04395
Size: 100 µg
Terminal: N/A
800.15 800.15 USD
AffiAB® CACNG2 Antibody
CAT# AFG-IVA-04394
Size: 100 µL
Terminal: N/A
597.65 597.65 USD
AffiAB® Cacng1 Antibody
CAT# AFG-IVA-04393
Size: 25 µL
Terminal: C-terminal
378.95 378.95 USD
AffiAB® CACNG3 Rabbit Polyclonal Antibody
CAT# AFG-EKA-07727
Size: 100 µL
246.00 246.0 USD
AffiAB® CACNG2 Rabbit Polyclonal Antibody
CAT# AFG-EKA-07726
Size: 100 µL
246.00 246.0 USD