ATP5G1 Antibodies

The ATP5G1 gene encodes a subunit of the mitochondrial ATP synthase complex. Mitochondrial ATP synthase, also known as complex V of the electron transport chain, is responsible for the synthesis of ATP (adenosine triphosphate), a key molecule involved in cellular energy production.

The ATP5G1 gene is specifically associated with the ATP synthase subunit g1. This subunit is part of the F0 complex of ATP synthase, which is embedded in the inner mitochondrial membrane. The F0 complex forms a proton channel that allows the flow of protons back into the mitochondrial matrix, and the energy from this proton flow is utilized by the F1 complex to convert ADP (adenosine diphosphate) and inorganic phosphate into ATP.

The ATP5G1 gene is essential for the proper assembly and function of the ATP synthase complex, and mutations in this gene or dysregulation of its expression can impact mitochondrial ATP production and cellular energy metabolism. Dysfunction of ATP synthase complexes is associated with various mitochondrial disorders and may contribute to conditions related to impaired energy production.