ARHGEF Antibodies

The ARHGEF (Rho Guanine Nucleotide Exchange Factor) gene family includes various genes that encode proteins acting as guanine nucleotide exchange factors (GEFs) for the Rho family of small GTPases. These GTPases are crucial regulators of cellular processes such as cytoskeletal dynamics, cell migration, and cell cycle progression. ARHGEF proteins specifically facilitate the activation of Rho GTPases by promoting the exchange of GDP (guanosine diphosphate) for GTP (guanosine triphosphate).

Several members of the ARHGEF gene family have been identified, and they play diverse roles in cellular functions. Here are a few examples:

ARHGEF1: Also known as p115-RhoGEF, it plays a role in RhoA activation and is involved in the regulation of cell migration.

ARHGEF2: Also known as LARG (Leukemia-Associated Rho Guanine Nucleotide Exchange Factor), it is involved in the activation of RhoA and has been associated with various cellular processes, including cell proliferation and migration.

ARHGEF3: It is involved in the regulation of cell morphology and is known to activate RhoA.

ARHGEF4: Also known as ASEF (ARHGEF4-Sec7 domain-containing protein), it plays a role in the regulation of cell morphology and migration and is implicated in cancer metastasis.

ARHGEF5: Also known as GEF-H1, it is involved in microtubule dynamics and the regulation of RhoA.

ARHGEF11: Also known as PDZ-RhoGEF, it plays a role in the regulation of RhoA and is associated with processes like smooth muscle contraction.

These are just a few examples, and there are additional ARHGEF genes with diverse functions. The ARHGEF family is important for understanding cellular signaling pathways, particularly those involved in cytoskeletal dynamics and cell motility. Research on ARHGEF genes is often relevant to cancer biology, development, and other physiological processes.