ALKBH Antibodies

The ALKBH (AlkB Homolog) gene family encodes for enzymes that possess AlkB (alkylated DNA repair protein) domain, which is involved in the repair of alkylated DNA lesions. Alkylation damage in DNA can occur due to exposure to certain environmental agents or endogenous metabolic processes, and repairing such damage is essential for maintaining genomic stability.

There are several members in the ALKBH gene family, and they are involved in various cellular processes, including DNA repair, RNA modification, and other functions. One well-known member of this gene family is ALKBH5.

Here are some key points:

ALKBH5 (AlkB Homolog 5): ALKBH5 is involved in the demethylation of N6-methyladenosine (m6A), a reversible RNA modification. This enzyme plays a role in the regulation of RNA metabolism and has been implicated in processes such as mRNA stability and translation.

DNA Repair: While ALKBH5 is more well-known for its role in RNA demethylation, other members of the ALKBH family, such as ALKBH2 and ALKBH3, are primarily involved in the repair of alkylated DNA lesions.

Cancer and Disease Associations: Dysregulation of ALKBH genes has been associated with certain cancers and other diseases. For example, altered expression of ALKBH5 has been observed in various cancer types, suggesting its potential role in tumorigenesis.

Epigenetic Regulation: ALKBH enzymes contribute to epigenetic regulation by modifying RNA and, in some cases, by affecting DNA methylation patterns.