![AffiAB® Anti-Ms CD19 PE [1D3]](/web/image/product.product/292979/image_1024/%5BAFG-XBO-2099%5D%20AffiAB%C2%AE%E2%80%8B%20Anti-Ms%20CD19%20PE%20%5B1D3%5D?unique=d31c23b)
Overview
CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity..
Species Reactivity
Mouse.
Antigen
CD19.
Negative Species
N/A.
Application
FC (QC tested) ) .
Immunogen
Mouse CD19-transfected cell line.
Clone
1D3.
Format
PE.
Isotype
Rat IgG2a.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide.
Storage & Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.