![AffiAB® Anti-Hu CD38 Biotin [HIT2]](/web/image/product.product/292195/image_1024/%5BAFG-XBO-1315%5D%20AffiAB%C2%AE%E2%80%8B%20Anti-Hu%20CD38%20Biotin%20%5BHIT2%5D?unique=d31c23b)
Overview
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. Another role of CD38 is provided by enzymatic activity of its extracellular part. CD38 acts as NAD+ glycohydrolase converting NAD+ into ADP-ribose, as ADP-ribosyl cyclase producing cADPR and as cADPR hydrolase, thus affecting levels of calcium-mobilizing metabolites. ADPR produced by CD38 serves as an important second messenger of neutrophil and dendritic cell migration..
Species Reactivity
Human.
Antigen
CD38.
Negative Species
N/A.
Application
FC (QC tested), WB, IHC (P), IHC (F) ) .
Immunogen
Human thymocytes in foetus.
Clone
HIT2.
Format
Biotin.
Isotype
Mouse IgG1.
Storage Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide.
Storage & Stability
Store at 2-8°C. Do not freeze.