![AffiAB® Anti-Hu CD274 PE-Cy7 [29E.2A3]](/web/image/product.product/291925/image_1024/%5BAFG-XBO-1045%5D%20AffiAB%C2%AE%E2%80%8B%20Anti-Hu%20CD274%20PE-Cy7%20%5B29E.2A3%5D?unique=0abe440)
Overview
CD274 / PD-L1 (programmed death ligand-1), also known as B7-H1, is a member of the B7 family of regulatory proteins. It can act as both costimulatory and coinhibitory molecule for T cells. Interaction with its receptor CD279 (PD1) appears to be important in the maintenance of peripheral tolerance and in prevention of tumor rejection. Even pathogens (e.g. Schistosoma) may exploit CD274 to evade an immune response. Besides CD279, existence of other receptor (s) for CD274 is likely..
Species Reactivity
Non-human primates, Human.
Antigen
CD274.
Negative Species
N/A.
Application
FC (QC tested) ) .
Immunogen
Full length human CD274.
Clone
29E.2A3.
Format
PE-Cy7.
Isotype
Mouse IgG2b kappa.
Storage Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide.
Storage & Stability
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.