AffiAB® 647 Conjugated Anti-Sodium Potassium ATPase Antibody [ST0533]

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CAT# AFG-HB-4297
Size: 100 μL

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    AffiAB® 647 Conjugated Anti-Sodium Potassium ATPase Antibody [ST0533]

    The sodium–potassium pump (sodium–potassium adenosine triphosphatase, also known as Na⁺/K⁺-ATPase, Na⁺/K⁺ pump, or sodium–potassium ATPase) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells. It performs several functions in cell physiology. The Na⁺/K⁺-ATPase helps maintain resting potential, affects transport, and regulates cellular volume. It also functions as a signal transducer/integrator to regulate the MAPK pathway, reactive oxygen species (ROS) , as well as intracellular calcium. In fact, all cells expend a large fraction of the ATP they produce (typically 30% and up to 70% in nerve cells) to maintain their required cytosolic Na and K concentrations. For neurons, the Na⁺/K⁺-ATPase can be responsible for up to 3/4 of the cell's energy expenditure. In many types of tissue, ATP consumption by the Na⁺/K⁺-ATPases have been related to glycolysis. This was first discovered in red blood cells (Schrier, 1966) , but has later been evidenced in renal cells, smooth muscles surrounding the blood vessels, [6] and cardiac purkinje cells. Recently, glycolysis has also been shown to be of particular importance for Na⁺/K⁺-ATPases in skeletal muscles, where inhibition of glycogen breakdown (a substrate for glycolysis) leads to reduced Na⁺/K⁺-ATPase activity and lower force production.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P05023 Human; SwissProt: P05026 Human; SwissProt: Q13733 Human; SwissProt: P06685 Rat; SwissProt: P07340 Rat; SwissProt: Q64541 Rat

    Recombinant

    YES

    Conjugation

    iFluor™ 647

    Host

    Rabbit

    Isotype

    IgG

    Clone

    ST0533

    KO/KD

    N/A

    Species reactivity

    Human, Mouse, Rat

    Tested applications

    IF-Tissue, FC

    Predicted species reactivity

    N/A

    Immunogen

    Synthetic peptide within Human ATP1A1 aa 39-83 / 1023.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Tissue: 1:100; FC: 1:500-1:1, 000

    Molecular Weight

    100 kDa

    Subcellular location

    Cell membrane, Melanosome.

    Positive control

    Rat kidney tissue, human liver tissue, Hela.

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