AffiAB® 647 Conjugated Anti-SATB2 Antibody [JM52-44]

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CAT# AFG-HB-4296
Size: 100 μL

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AffiAB® 647 Conjugated Anti-SATB2 Antibody [JM52-44]

SATB2 (Special AT-rich sequence-binding protein 2) is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regulating skeletal development and osteoblast differentiation. Highly expressed in adult and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix-attachment regions (MARs) and regulate MAR-dependent transcription of various genes, including HoxA2 and ATF4 (CREB-2) , involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: Q9UPW6 Human

Recombinant

YES

Conjugation

iFluor™ 647

Host

Rabbit

Isotype

IgG

Clone

JM52-44

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

IF-Tissue, FC

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within Human SATB2 238-287 / 733.

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Tissue: 1:200; FC: 1:500-1:1, 000

Molecular Weight

Predicted band size: 83 kDa

Subcellular location

Nucleus matrix.

Positive control

Human colon carcinoma tissue, THP-1.