AffiAB® 647 Conjugated Anti-SATB2 Antibody [JM52-44]

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CAT# AFG-HB-4296
Size: 100 μL

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    AffiAB® 647 Conjugated Anti-SATB2 Antibody [JM52-44]

    SATB2 (Special AT-rich sequence-binding protein 2) is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regulating skeletal development and osteoblast differentiation. Highly expressed in adult and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix-attachment regions (MARs) and regulate MAR-dependent transcription of various genes, including HoxA2 and ATF4 (CREB-2) , involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: Q9UPW6 Human

    Recombinant

    YES

    Conjugation

    iFluor™ 647

    Host

    Rabbit

    Isotype

    IgG

    Clone

    JM52-44

    KO/KD

    N/A

    Species reactivity

    Human, Mouse, Rat

    Tested applications

    IF-Tissue, FC

    Predicted species reactivity

    N/A

    Immunogen

    Synthetic peptide within Human SATB2 238-287 / 733.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Tissue: 1:200; FC: 1:500-1:1, 000

    Molecular Weight

    Predicted band size: 83 kDa

    Subcellular location

    Nucleus matrix.

    Positive control

    Human colon carcinoma tissue, THP-1.

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