AffiAB® 647 Conjugated Anti-pan Cytokeratin Antibody [PD00-15]

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CAT# AFG-HB-4295
Size: 100 μL

315.00 315.0 USD 315.00

315.00

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AffiAB® 647 Conjugated Anti-pan Cytokeratin Antibody [PD00-15]

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. For example, cytokeratins 10 and 13 are expressed highly in a subset of squamous cell carcinomas while cytokeratin 18 is expressed in a majority of adenocarcinomas and basal cell carcinomas. Since each epithelium contains at least one acidic and one basic keratin, this antibody is used to observe the distribution of keratin-containing cells in normal epithelia and to identify neoplasms derived from such epithelium.

Antibody type

Recombinant Mouse monoclonal Antibody

Uniprot ID

SwissProt: Q01546 Human; SwissProt: Q7Z794 Human

Recombinant

YES

Conjugation

iFluor™ 647

Host

Mouse

Isotype

N/A

Clone

PD00-15

KO/KD

N/A

Species reactivity

Human

Tested applications

IF-Tissue, FC

Predicted species reactivity

N/A

Immunogen

Synthetic peptide.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

PBS (pH7.4) , 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Tissue: 1:200; FC: 1:500-1:1, 000

Molecular Weight

N/A

Subcellular location

Cytoplasm.

Positive control

Human breast tissue, MCF-7.