AffiAB® 647 Conjugated Anti-Glucose Transporter GLUT1 Antibody [SA0377]

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CAT# AFG-HB-4292
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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AffiAB® 647 Conjugated Anti-Glucose Transporter GLUT1 Antibody [SA0377]

Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. In adipose and muscle tissue, insulin stimulates a rapid and dramatic increase in glucose uptake, which is largely due to the redistribution of the insulin-inducible glucose transporter, Glut4. In response to insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane, and shows a much less dramatic translocation in response to insulin. Glut1 and Glut4 are twelve-pass transmembrane proteins (12TM) whose carboxy-termini may dictate their cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P11166 Human; SwissProt: P17809 Mouse

Recombinant

YES

Conjugation

iFluor™ 647

Host

Rabbit

Isotype

IgG

Clone

SA0377

KO/KD

N/A

Species reactivity

Human, Mouse

Tested applications

IF-Tissue

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within Human GLUT1 aa 443-492 / 492.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Tissue: 1:200

Molecular Weight

Predicted band size: 54 kDa

Subcellular location

Cell membrane, Melanosome

Positive control

Human placenta tissue.