AffiAB® 647 Conjugated Anti-Cytokeratin 8 Antibody [SU0338]

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CAT# AFG-HB-4290
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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    AffiAB® 647 Conjugated Anti-Cytokeratin 8 Antibody [SU0338]

    Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. They have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 8 expression is seen in epithelium and epithelium-derived tumors. Cytokeratin 8 is often used together with keratin 18 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P05787 Human; SwissProt: P11679 Mouse

    Recombinant

    YES

    Conjugation

    iFluor™ 647

    Host

    Rabbit

    Isotype

    IgG

    Clone

    SU0338

    KO/KD

    N/A

    Species reactivity

    Human, Mouse

    Tested applications

    IF-Cell, IF-Tissue

    Predicted species reactivity

    N/A

    Immunogen

    Synthetic peptide within Human Cytokeratin 8 aa 321-370 / 483.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Cell: 1:100; IF-Tissue: 1:200

    Molecular Weight

    Predicted band size: 54 kDa

    Subcellular location

    Nucleoplasm, Nucleus matrix, Cytoplasm.

    Positive control

    SK-Br-3, human breast tissue.

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