AffiAB® 647 Conjugated Anti-Cytokeratin 8 Antibody [SU0338]

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CAT# AFG-HB-4290
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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AffiAB® 647 Conjugated Anti-Cytokeratin 8 Antibody [SU0338]

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. They have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 8 expression is seen in epithelium and epithelium-derived tumors. Cytokeratin 8 is often used together with keratin 18 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P05787 Human; SwissProt: P11679 Mouse

Recombinant

YES

Conjugation

iFluor™ 647

Host

Rabbit

Isotype

IgG

Clone

SU0338

KO/KD

N/A

Species reactivity

Human, Mouse

Tested applications

IF-Cell, IF-Tissue

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within Human Cytokeratin 8 aa 321-370 / 483.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Cell: 1:100; IF-Tissue: 1:200

Molecular Weight

Predicted band size: 54 kDa

Subcellular location

Nucleoplasm, Nucleus matrix, Cytoplasm.

Positive control

SK-Br-3, human breast tissue.