AffiAB® 647 Conjugated Anti-Cytokeratin 7 Antibody [ST50-05]

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CAT# AFG-HB-4289
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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AffiAB® 647 Conjugated Anti-Cytokeratin 7 Antibody [ST50-05]

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. Cytokeratin 7 (also known as sarcolectin) agglutinates normal and transformed cells with a high affinity for simple sugars. Cytokeratin 7 also inhibits the synthesis of interferon-dependent secondary proteins thus reversing the antiviral effect of interferon induction and restoring cells to their status ad primum. In normal and transformed cells, Cytokeratin 7 localizes to the membrane.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P08729 Human; SwissProt: Q9DCV7 Mouse

Recombinant

YES

Conjugation

iFluor™ 647

Host

Rabbit

Isotype

IgG

Clone

ST50-05

KO/KD

N/A

Species reactivity

Human, Mouse

Tested applications

IF-Cell, IF-Tissue

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within Human Cytokeratin 7 aa 18-67.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Cell: 1:100; IF-Tissue: 1:50-1:200

Molecular Weight

Predicted band size: 51 kDa

Subcellular location

Cytoplasm.

Positive control

SK-Br-3, human liver tissue, human breast tissue.