AffiAB® 647 Conjugated Anti-Cytokeratin 6 Antibody [SN71-07]

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CAT# AFG-HB-4288
Size: 100 μL

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    AffiAB® 647 Conjugated Anti-Cytokeratin 6 Antibody [SN71-07]

    Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins, which are useful markers of tissue differentiation, also aid in the characterization of malignant tumors. IL-1 and TNFα induce transcription of cytokeratin 6 in epidermal keratinocytes via the C/EBP β transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F) , encoded by several highly homologous genes, have distinct tissue expression patterns, and cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P02538 Human; SwissProt: P04259 Human; SwissProt: P48668 Human; SwissProt:Q4FZU2 Rat

    Recombinant

    YES

    Conjugation

    iFluor™ 647

    Host

    Rabbit

    Isotype

    IgG

    Clone

    SN71-07

    KO/KD

    N/A

    Species reactivity

    Human, Rat

    Tested applications

    IF-Cell, IF-Tissue

    Predicted species reactivity

    N/A

    Immunogen

    Recombinant protein within Human Cytokeratin 6 aa 1-118 / 564.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Cell: 1:100; IF-Tissue: 1:100

    Molecular Weight

    Predicted band size: 60 kDa

    Subcellular location

    N/A

    Positive control

    A431, human tonsil tissue.

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