AffiAB® 647 Conjugated Anti-Cytokeratin 4 Antibody [SN74-03]

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CAT# AFG-HB-4286
Size: 100 μL

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    AffiAB® 647 Conjugated Anti-Cytokeratin 4 Antibody [SN74-03]

    Cytokeratins are a subfamily of intermediate filament keratins that are characterized by a remarkable biochemical diversity, which is represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in isoelectric range between 4.9 and 7.8. Cytokeratin 1 has the highest molecular weight, while Cytokeratin 19 has the lowest molecular weight. The cytokeratins are divided into the type I and type II subgroups. Type II family members comprise the basic to neutral members, Cytokeratins 1-8, while the type I group comprises the acidic members, Cytokeratins 9-20. Various epithelia in the human body usually express cytokeratins which are characteristic of the type of epithelium and related to the degree of maturation or differentiation within said epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. Cytokeratin 4 is expressed in differentiated layers of the mucosal and esophageal epithelia along with Cytokeratin 13.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P19013 Human

    Recombinant

    YES

    Conjugation

    iFluor™ 647

    Host

    Rabbit

    Isotype

    IgG

    Clone

    SN74-03

    KO/KD

    N/A

    Species reactivity

    Human

    Tested applications

    IF-Cell, IF-Tissue

    Predicted species reactivity

    N/A

    Immunogen

    Recombinant protein within Human Cytokeratin 4 aa 395-520.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Cell: 1:100; IF-Tissue: 1:200

    Molecular Weight

    Predicted band size: 56 kDa

    Subcellular location

    Cell surface, intermediate filament cytoskeleton, nucleus.

    Positive control

    A431, human tonsil tissue.

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