AffiAB® 647 Conjugated Anti-Cytokeratin 4 Antibody [SN74-03]

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CAT# AFG-HB-4286
Size: 100 μL

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AffiAB® 647 Conjugated Anti-Cytokeratin 4 Antibody [SN74-03]

Cytokeratins are a subfamily of intermediate filament keratins that are characterized by a remarkable biochemical diversity, which is represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in isoelectric range between 4.9 and 7.8. Cytokeratin 1 has the highest molecular weight, while Cytokeratin 19 has the lowest molecular weight. The cytokeratins are divided into the type I and type II subgroups. Type II family members comprise the basic to neutral members, Cytokeratins 1-8, while the type I group comprises the acidic members, Cytokeratins 9-20. Various epithelia in the human body usually express cytokeratins which are characteristic of the type of epithelium and related to the degree of maturation or differentiation within said epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. Cytokeratin 4 is expressed in differentiated layers of the mucosal and esophageal epithelia along with Cytokeratin 13.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P19013 Human

Recombinant

YES

Conjugation

iFluor™ 647

Host

Rabbit

Isotype

IgG

Clone

SN74-03

KO/KD

N/A

Species reactivity

Human

Tested applications

IF-Cell, IF-Tissue

Predicted species reactivity

N/A

Immunogen

Recombinant protein within Human Cytokeratin 4 aa 395-520.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Cell: 1:100; IF-Tissue: 1:200

Molecular Weight

Predicted band size: 56 kDa

Subcellular location

Cell surface, intermediate filament cytoskeleton, nucleus.

Positive control

A431, human tonsil tissue.