AffiAB® 647 Conjugated Anti-Cytokeratin 18 Antibody [SZ80-07]

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CAT# AFG-HB-4284
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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    AffiAB® 647 Conjugated Anti-Cytokeratin 18 Antibody [SZ80-07]

    Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratin 18 is a type I cytokeratin. It is, together with its filament partner Cytokeratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Keratin 18 is often used together with Cytokeratin 8 and Cytokeratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P05783 Human; SwissProt: P05784 Mouse; SwissProt: Q5BJY9 Rat

    Recombinant

    YES

    Conjugation

    iFluor™ 647

    Host

    Rabbit

    Isotype

    IgG

    Clone

    SZ80-07

    KO/KD

    N/A

    Species reactivity

    Human, Mouse, Rat

    Tested applications

    IF-Tissue

    Predicted species reactivity

    N/A

    Immunogen

    Recombinant protein within mouse Cytokeratin 18 aa 200-423.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Tissue: 1:50

    Molecular Weight

    Predicted band size: 48 kDa

    Subcellular location

    Cytoplasm, Nucleus.

    Positive control

    Human liver tissue.

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