AffiAB® 647 Conjugated Anti-Cytokeratin 18 Antibody [SZ80-07]

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CAT# AFG-HB-4284
Size: 100 μL

386.10 386.1 USD 386.10

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AffiAB® 647 Conjugated Anti-Cytokeratin 18 Antibody [SZ80-07]

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratin 18 is a type I cytokeratin. It is, together with its filament partner Cytokeratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Keratin 18 is often used together with Cytokeratin 8 and Cytokeratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P05783 Human; SwissProt: P05784 Mouse; SwissProt: Q5BJY9 Rat

Recombinant

YES

Conjugation

iFluor™ 647

Host

Rabbit

Isotype

IgG

Clone

SZ80-07

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

IF-Tissue

Predicted species reactivity

N/A

Immunogen

Recombinant protein within mouse Cytokeratin 18 aa 200-423.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Tissue: 1:50

Molecular Weight

Predicted band size: 48 kDa

Subcellular location

Cytoplasm, Nucleus.

Positive control

Human liver tissue.