AffiAB® 647 Conjugated Anti-Cytokeratin 14 Antibody [SC65-06]

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CAT# AFG-HB-4280
Size: 100 μL

386.10 386.1 USD 386.10

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AffiAB® 647 Conjugated Anti-Cytokeratin 14 Antibody [SC65-06]

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. The gene encoding human Cytokeratin 14 maps to chromosome 17q12-21. Mutations in this gene lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P02533 Human; SwissProt: Q6IFV1 Rat

Recombinant

YES

Conjugation

iFluor™ 647

Host

Rabbit

Isotype

IgG

Clone

SC65-06

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

IF-Cell, IF-Tissue

Predicted species reactivity

N/A

Immunogen

Recombinant protein within Human Cytokeratin 14 aa 250-484.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Cell: 1:100; IF-Tissue: 1:400

Molecular Weight

Predicted band size: 52 kDa

Subcellular location

Cytoplasm, Nucleus.

Positive control

A431, rat skin tissue.