AffiAB® 594 Conjugated Anti-S100 beta Antibody [SC57-02]

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CAT# AFG-HB-4274
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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AffiAB® 594 Conjugated Anti-S100 beta Antibody [SC57-02]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P04271 Human; SwissProt: P50114 Mouse; SwissProt: P04631 Rat

Recombinant

YES

Conjugation

iFluor™ 594

Host

Rabbit

Isotype

IgG

Clone

SC57-02

KO/KD

N/A

Species reactivity

Human

Tested applications

IF-Tissue

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within C-terminal human S100 beta.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Tissue: 1:50-1:200

Molecular Weight

11 kDa

Subcellular location

Cytoplasm, Nucleus.

Positive control

human malignant melanoma tissue, human meningioma tissue.