AffiAB® 594 Conjugated Anti-GFAP Antibody [1-D4]

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CAT# AFG-HB-4271
Size: 100 μL

354.60 354.6 USD 354.60

354.60

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    AffiAB® 594 Conjugated Anti-GFAP Antibody [1-D4]

    Glial fibrillary acidic protein (GFAP) is an intermediate filament protein. The protein is the smallest (8 nm) of the intermediate filament proteins with a molecular weight of about 51 kDa. In the central nervous system, GFAP is expressed in astrocytes and ependymal cells but not in other glial cells. However, immature oligodendrocytes and immature choroid plexus cells may be GFAP positive. In the peripheral nervous system enteric Schwann cells and satellite cells of human sensory ganglia express GFAP. Outside the nervous system, GFAP is seen in myoepithelial cells and chondroblasts, in the former coexpressed with cytokeratin, in the latter coexpressed with vimentin. Astrocytoma, ependymoma, glioblastoma, and oligodendroglioma are almost always positive. Plexus carcinoma, ganglioglioma and primitive neuroectodermal tumours (PNET: neuroblastoma a.o.) express GFAP to a varying extent. Schwannoma and neurofibroma frequently express GFAP. Chondroma, chondrosarcoma and pleomorphic adenoma are also GFAP positive in most cases. A few carcinomas (especially from lung and breast) may express GFAP. in paraganglioma GFAP may be detected in sustentacular cells.

    Antibody type

    Mouse monoclonal Antibody

    Uniprot ID

    SwissProt: P14136 Human; SwissProt: P03995 Mouse; SwissProt: P47819 Rat

    Recombinant

    NO

    Conjugation

    iFluor™ 594

    Host

    Mouse

    Isotype

    IgG1

    Clone

    1-D4

    KO/KD

    N/A

    Species reactivity

    Human, Mouse, Rat

    Tested applications

    IF-Tissue

    Predicted species reactivity

    N/A

    Immunogen

    Synthetic peptide within C-terminal human GFAP.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

    Concentration

    2 mg/mL.

    Purity

    Protein G affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Tissue: 1:200

    Molecular Weight

    50 kDa

    Subcellular location

    Cytoplasm.

    Positive control

    Mouse brain tissue, rat brain tissue, rat cerebellum tissue.

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