AffiAB® 594 Conjugated Anti-Cytokeratin 8 Antibody [SU0338]

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CAT# AFG-HB-4269
Size: 100 μL

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AffiAB® 594 Conjugated Anti-Cytokeratin 8 Antibody [SU0338]

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. They have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 8 expression is seen in epithelium and epithelium-derived tumors. The Cytokeratin 8 and 18 pair are normally expressed in simple epithelia, but not in stratified epithelial cells. Research indicates that squamous cell carcinomas derived from stratified epithelia show abnormal expression of Cytokeratin 8 and 18, although it is not known whether these proteins contribute to the malignant phenotype of the cells. Expression of Cytokeratin 8 and 18 in oral squamous cell carcinomas is an independent prognostic marker that indicates a poor prognosis. Cytokeratin 8 expression correlates with malignancy in leukoplakia and carcinomas of the head and neck; it is expressed in all non-small-cell lung cancers. Cytokeratin 8 has been shown to possess extracellular epitopes on tumor cells, which may represent valuable targets for therapy.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P05787 Human; SwissProt: P11679 Mouse

Recombinant

YES

Conjugation

iFluor™ 594

Host

Rabbit

Isotype

IgG

Clone

SU0338

KO/KD

N/A

Species reactivity

Human

Tested applications

IF-Cell, IF-Tissue, FC

Predicted species reactivity

Mouse

Immunogen

Synthetic peptide within Human Cytokeratin 8 aa 321-370 / 483.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Cell: 1:50; IF-Tissue: 1:100-1:400; FC: 1:500-1:1, 000

Molecular Weight

Predicted band size: 54 kDa

Subcellular location

Nucleoplasm, Nucleus matrix, Cytoplasm.

Positive control

Human breast tissue, human liver tissue, SK-Br-3, A431.