AffiAB® 594 Conjugated Anti-Cytokeratin 16 Antibody [SC52-09]

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CAT# AFG-HB-4263
Size: 100 μL

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AffiAB® 594 Conjugated Anti-Cytokeratin 16 Antibody [SC52-09]

Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1) , nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN) .

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P08779 Human

Recombinant

YES

Conjugation

iFluor™ 594

Host

Rabbit

Isotype

IgG

Clone

SC52-09

KO/KD

N/A

Species reactivity

Human

Tested applications

IF-Cell, IF-Tissue

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within human Cytokeratin 16 aa 27-75.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Cell: 1:50; IF-Tissue: 1:50

Molecular Weight

Predicted band size: 51 kDa

Subcellular location

Cytoskeleton, Nucleus.

Positive control

A431, human esophagus tissue.