AffiAB® 594 Conjugated Anti-Cytokeratin 15 Antibody [ST04-85]

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CAT# AFG-HB-4262
Size: 100 μL

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    AffiAB® 594 Conjugated Anti-Cytokeratin 15 Antibody [ST04-85]

    Cytokeratin 15 (CK15, K15, K1CO, keratin15, type I cytoskeletal 15) is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Keratin family members are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains, and are clustered in a region on chromosome 17q21.2. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P19012 Human; SwissProt: Q61414 Mouse; SwissProt: Q6IFV3 Rat

    Recombinant

    YES

    Conjugation

    iFluor™ 594

    Host

    Rabbit

    Isotype

    IgG

    Clone

    ST04-85

    KO/KD

    N/A

    Species reactivity

    Human, Mouse, Rat

    Tested applications

    IF-Tissue

    Predicted species reactivity

    N/A

    Immunogen

    Synthetic peptide within Human Cytokeratin 15 aa 410-455.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Tissue: 1:100-1:400

    Molecular Weight

    49 kDa

    Subcellular location

    Intermediate filament, cytosol, extracellular exosome, nucleus.

    Positive control

    Human skin tissue, rat skin tissue.

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