AffiAB® 594 Conjugated Anti-Cytokeratin 15 Antibody [ST04-85]

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CAT# AFG-HB-4262
Size: 100 μL

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AffiAB® 594 Conjugated Anti-Cytokeratin 15 Antibody [ST04-85]

Cytokeratin 15 (CK15, K15, K1CO, keratin15, type I cytoskeletal 15) is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Keratin family members are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains, and are clustered in a region on chromosome 17q21.2. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceus. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P19012 Human; SwissProt: Q61414 Mouse; SwissProt: Q6IFV3 Rat

Recombinant

YES

Conjugation

iFluor™ 594

Host

Rabbit

Isotype

IgG

Clone

ST04-85

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

IF-Tissue

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within Human Cytokeratin 15 aa 410-455.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Tissue: 1:100-1:400

Molecular Weight

49 kDa

Subcellular location

Intermediate filament, cytosol, extracellular exosome, nucleus.

Positive control

Human skin tissue, rat skin tissue.