AffiAB® 594 Conjugated Anti-Cytokeratin 1 Antibody [SN72-08]

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CAT# AFG-HB-4259
Size: 100 μL

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    AffiAB® 594 Conjugated Anti-Cytokeratin 1 Antibody [SN72-08]

    Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins constitute up to 85% of a mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10-nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and they aid in the characterization of malignant tumors. Cytokeratin 1 is highly expressed in several malignancies including epithelioid hemangioendohtheliomas, angiosarcomas, schwannomas, epithelioid sarcomas and synodal sarcomas. The gene encoding human Cytokeratin 1 maps to chromosome 12q13.13. Mutations in the gene encoding human Cytokeratin 1 lead to abnormal filament associations and epidermolytic hyperkeratosis.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P04264 Human; SwissProt: P04104 Mouse; SwissProt: Q6IMF3 Rat

    Recombinant

    YES

    Conjugation

    iFluor™ 594

    Host

    Rabbit

    Isotype

    IgG

    Clone

    SN72-08

    KO/KD

    N/A

    Species reactivity

    Human, Mouse, Rat

    Tested applications

    IF-Tissue

    Predicted species reactivity

    N/A

    Immunogen

    Synthetic peptide within mouse Cytokeratin 1 aa 586-637.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Tissue: 1:50-1:100

    Molecular Weight

    66 kDa

    Subcellular location

    Cell membrane.

    Positive control

    Human skin tissue.

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