AffiAB® 488 Conjugated Anti-Lamin B1 Antibody [SI17-07]

https://www.affiab.com/web/image/product.template/116628/image_1920?unique=136d80a

CAT# AFG-HB-4251
Size: 100 μL

386.10 386.1 USD 386.10

386.10

For Price contact us on info@gentaur.com

    This combination does not exist.

    Terms and Conditions
    14-day money-back guarantee
    Shipping: 1-3 Weeks

    AffiAB® 488 Conjugated Anti-Lamin B1 Antibody [SI17-07]

    A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/ICE, functions as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Nuclear lamins are critical to maintaining the integrity of the nuclear envelope and cellular morphology as components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P20700 Human; SwissProt: P14733 Mouse; SwissProt: P70615 Rat

    Recombinant

    YES

    Conjugation

    iFluor™ 488

    Host

    Rabbit

    Isotype

    IgG

    Clone

    SI17-07

    KO/KD

    N/A

    Species reactivity

    Human, Mouse, Rat

    Tested applications

    IF-Tissue

    Predicted species reactivity

    N/A

    Immunogen

    Synthetic peptide within Human Lamin B1 aa 511-560 / 586.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Tissue: 1:200

    Molecular Weight

    Predicted band size: 66 kDa

    Subcellular location

    Nucleus inner membrane.

    Positive control

    Human colon carcinoma tissue, mouse colon tissue, rat colon tissue.

    Related Products

    Your Dynamic Snippet will be displayed here... This message is displayed because you did not provided both a filter and a template to use.