AffiAB® 488 Conjugated Anti-Iba1 Antibody [JM36-62]

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CAT# AFG-HB-4249
Size: 100 μL

386.10 386.1 USD 386.10

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AffiAB® 488 Conjugated Anti-Iba1 Antibody [JM36-62]

Ionized calcium-binding adapter molecule 1 (Iba1) , also known as allograft inflammatory factor-1 (AIF-1) , is a 147 amino acid cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. Iba1, containing two EF domains, is induced by cytokines and interferons. In an unstimulated state, Iba1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding Iba1 maps to chromosome 6p21.33 and resides in the tumor necrosis factor (TNF) cluster of genes located in the region represented by the human major histocompatibility complex (MHC) .

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P55008 Human; SwissProt: O70200 Mouse; SwissProt: P55009 Rat

Recombinant

YES

Conjugation

iFluor™ 488

Host

Rabbit

Isotype

IgG

Clone

JM36-62

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

IF-Cell, FC

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within N-terminal human Iba1.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Cell: 1:100; FC: 1:500-1:1, 000

Molecular Weight

Predicted band size: 17 kDa

Subcellular location

Cytoskeleton, ruffle membrane, phagocytic cup.

Positive control

SH-SY5Y.