AffiAB® 488 Conjugated Anti-Glucose Transporter GLUT1 Antibody [SA0377]

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CAT# AFG-HB-4248
Size: 100 μL

386.10 386.1 USD 386.10

386.10

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    AffiAB® 488 Conjugated Anti-Glucose Transporter GLUT1 Antibody [SA0377]

    Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. In adipose and muscle tissue, insulin stimulates a rapid and dramatic increase in glucose uptake, which is largely due to the redistribution of the insulin-inducible glucose transporter, Glut4. In response to insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane, and shows a much less dramatic translocation in response to insulin. Glut1 and Glut4 are twelve-pass transmembrane proteins (12TM) whose carboxy-termini may dictate their cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity.

    Antibody type

    Recombinant Rabbit monoclonal Antibody

    Uniprot ID

    SwissProt: P11166 Human; SwissProt: P17809 Mouse; SwissProt: P11167 Rat

    Recombinant

    YES

    Conjugation

    iFluor™ 488

    Host

    Rabbit

    Isotype

    IgG

    Clone

    SA0377

    KO/KD

    N/A

    Species reactivity

    Human, Mouse

    Tested applications

    IF-Cell, IF-Tissue

    Predicted species reactivity

    Rat

    Immunogen

    Synthetic peptide within Human GLUT1 aa 443-492 / 492.

    Storage

    Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

    Form

    Liquid

    Storage buffer

    Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

    Concentration

    1 mg/mL.

    Purity

    Protein A affinity purified.

    Signal pathway

    N/A

    Recommended dilutions

    IF-Cell: 1:100; IF-Tissue: 1:50

    Molecular Weight

    Predicted band size: 54 kDa

    Subcellular location

    Cell membrane, Melanosome

    Positive control

    MCF-7, human placenta tissue.

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