AffiAB® 488 Conjugated Anti-GFAP Antibody [1-D4]

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CAT# AFG-HB-4247
Size: 100 μL

354.60 354.6 USD 354.60

354.60

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AffiAB® 488 Conjugated Anti-GFAP Antibody [1-D4]

Glial fibrillary acidic protein (GFAP) is an intermediate filament protein. The protein is the smallest (8 nm) of the intermediate filament proteins with a molecular weight of about 51 kDa. In the central nervous system, GFAP is expressed in astrocytes and ependymal cells but not in other glial cells. However, immature oligodendrocytes and immature choroid plexus cells may be GFAP positive. In the peripheral nervous system enteric Schwann cells and satellite cells of human sensory ganglia express GFAP. Outside the nervous system, GFAP is seen in myoepithelial cells and chondroblasts, in the former coexpressed with cytokeratin, in the latter coexpressed with vimentin. Astrocytoma, ependymoma, glioblastoma, and oligodendroglioma are almost always positive. Plexus carcinoma, ganglioglioma and primitive neuroectodermal tumours (PNET: neuroblastoma a.o.) express GFAP to a varying extent. Schwannoma and neurofibroma frequently express GFAP. Chondroma, chondrosarcoma and pleomorphic adenoma are also GFAP positive in most cases. A few carcinomas (especially from lung and breast) may express GFAP. in paraganglioma GFAP may be detected in sustentacular cells.

Antibody type

Mouse monoclonal Antibody

Uniprot ID

SwissProt: P14136 Human; SwissProt: P03995 Mouse; SwissProt: P47819 Rat

Recombinant

NO

Conjugation

iFluor™ 488

Host

Mouse

Isotype

IgG1

Clone

1-D4

KO/KD

N/A

Species reactivity

Human, Mouse, Rat

Tested applications

IF-Tissue

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within C-terminal human GFAP.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

2 mg/mL.

Purity

Protein G affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Tissue: 1:100-1:200

Molecular Weight

50 kDa

Subcellular location

Cytoplasm.

Positive control

Rat brain tissue.