AffiAB® 488 Conjugated Anti-GFAP Antibody [1-D4]
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein. The protein is the smallest (8 nm) of the intermediate filament proteins with a molecular weight of about 51 kDa. In the central nervous system, GFAP is expressed in astrocytes and ependymal cells but not in other glial cells. However, immature oligodendrocytes and immature choroid plexus cells may be GFAP positive. In the peripheral nervous system enteric Schwann cells and satellite cells of human sensory ganglia express GFAP. Outside the nervous system, GFAP is seen in myoepithelial cells and chondroblasts, in the former coexpressed with cytokeratin, in the latter coexpressed with vimentin. Astrocytoma, ependymoma, glioblastoma, and oligodendroglioma are almost always positive. Plexus carcinoma, ganglioglioma and primitive neuroectodermal tumours (PNET: neuroblastoma a.o.) express GFAP to a varying extent. Schwannoma and neurofibroma frequently express GFAP. Chondroma, chondrosarcoma and pleomorphic adenoma are also GFAP positive in most cases. A few carcinomas (especially from lung and breast) may express GFAP. in paraganglioma GFAP may be detected in sustentacular cells.
Mouse monoclonal Antibody
SwissProt: P14136 Human; SwissProt: P03995 Mouse; SwissProt: P47819 Rat
Human, Mouse, Rat
Predicted species reactivity
Synthetic peptide within C-terminal human GFAP.
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS
Protein G affinity purified.
Rat brain tissue.