AffiAB® 488 Conjugated Anti-E-Cadherin Antibody [SY0287]

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CAT# AFG-HB-4245
Size: 100 μL

386.10 386.1 USD 386.10

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AffiAB® 488 Conjugated Anti-E-Cadherin Antibody [SY0287]

Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin-6) , R-cadherin, B-cadherin, E/P cadherin and cadherin-5. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxy terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function.

Antibody type

Recombinant Rabbit monoclonal Antibody

Uniprot ID

SwissProt: P12830 Human

Recombinant

YES

Conjugation

iFluor™ 488

Host

Rabbit

Isotype

IgG

Clone

SY0287

KO/KD

N/A

Species reactivity

Human

Tested applications

IF-Cell, FC

Predicted species reactivity

N/A

Immunogen

Synthetic peptide within Human E-Cadherin aa 591-640 / 882.

Storage

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Form

Liquid

Storage buffer

Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS

Concentration

1 mg/mL.

Purity

Protein A affinity purified.

Signal pathway

N/A

Recommended dilutions

IF-Cell: 1:100; FC: 1:50-1:1, 000

Molecular Weight

Predicted band size: 97 kDa

Subcellular location

Endosome, Cell membrane, trans-Golgi network, adherens junction.

Positive control

MCF-7, A431.